SKINLUMIS
Skinlumis Intelligence Vault

Peer-reviewed research. Translated for real life.

Every study read for the result, the mechanism, and what it means for your routine. No press releases, no affiliate links, no marketing.

285 studies indexed100 high-evidenceUpdated dailyLast update · 12/1/2026
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Featured Research
ingredientsRCT
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Evaluation of Nicotinamide Riboside in Prevention of Small Nerve Fiber Axon Degeneration and Promotion of Nerve Regeneration.

J Peripher Nerv Syst · Mar 2026

Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.

niacinamidepharctingredients
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Acne Research · 105 studies

Inflammation, follicular plugging, sebaceous biology, what the evidence supports.

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ingredientsOpinion

An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy.

J Funct Biomater · May 2026

This study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality. These ingredients are increasingly recognized for their synergistic effects in aesthetic medicine, with HA and PN providing hydration and skin support, and niacinamide offering anti-inflammatory and antioxidant properties. A prospective, open-label clinical investigation was conducted on 42 female subjects (mean age 45 ± 1 years, Fitzpatrick skin phototypes II-V) to assess skin elasticity, hydration, and mild skin depression correction following cheek area injections.

niacinamidehyaluronic_acidpha
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ingredientsSystematic Review

Efficacy and safety of recombinant human epidermal growth factor combined with fractional carbon dioxide laser for facial atrophic acne scars: a systematic review and meta-analysis of randomized trials.

Lasers Med Sci · May 2026

The combination of recombinant human epidermal growth factor (rhEGF) and fractional carbon dioxide (CO2) laser therapy is increasingly used in the treatment of facial atrophic acne scars. This study aimed to systematically assess the efficacy and safety of rhEGF combined with fractional CO2 laser therapy for managing facial atrophic acne scars. PubMed, Embase, the Cochrane Library, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, SinoMed, and VIP were searched from inception to July 29, 2025.

centellaacneaging
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ingredientsSystematic Review

L-Carnitine in Dermatology: A Systematic Review of Therapeutic Potential and Biomarker Applications.

J Cutan Med Surg · Mar 2026

L-Carnitine, an amino acid derivative critical for fatty acid metabolism, exhibits anti-inflammatory, antioxidant, and cytoprotective properties, with emerging applications in dermatology. This review explores its therapeutic potential, both topically and systemically, and its role as a biomarker in various skin disorders. A systematic search of Medline, EMBASE, and PubMed (1946-January 2025) was conducted, focusing on L-carnitine and dermatologic conditions, excluding acetyltransferases, acyltransferases, breast, and genetic metabolic diseases.

retinolsalicylic_acidacne
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regulationSystematic Review

Applications of bakuchiol in dermatology: Systematic review of the literature.

J Cosmet Dermatol · Dec 2022

Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti-aging, anti-inflammatory, and antibacterial properties. The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient in skincare. Our aim was to review the data for the applications of BAK in dermatology.

retinolbakuchiolacne
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ingredientsSystematic Review

Iontophoresis-Based Topical Drug Delivery for Dermatologic Conditions: A Systematic Review.

Pharmaceuticals (Basel) · May 2026

The efficacy of topical therapies in dermatology is often limited by the barrier function of the stratum corneum, which restricts drug penetration. Iontophoresis is a non-invasive transdermal delivery technique that uses a low-intensity electrical current to enhance the transport of charged and polar molecules across the skin. It has emerged as a strategy to improve local drug bioavailability while minimizing systemic exposure.

phaacnehyperpigmentation
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protocolsRCT

Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study.

J Cosmet Dermatol · Jan 2026

Dermocosmetics have proven their benefit in acne management. However, only very few studies investigated their efficacy kinetics. This study assessed the efficacy kinetics of a dermocosmetic cream (DC) containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis in subjects with acne.

niacinamidesalicylic_acidzinc
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Aging Research · 112 studies

Photoaging, collagen biology, the long-term mechanics of skin time.

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ingredientsSystematic Review

Does Astragalus mongholicus Bunge help promote the healing of wounds? A systematic review and meta-analysis of preclinical animal studies.

Front Pharmacol · Jan 2026

Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.

phacollagensystematic_review
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ingredientsOpinion

An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy.

J Funct Biomater · May 2026

This study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality. These ingredients are increasingly recognized for their synergistic effects in aesthetic medicine, with HA and PN providing hydration and skin support, and niacinamide offering anti-inflammatory and antioxidant properties. A prospective, open-label clinical investigation was conducted on 42 female subjects (mean age 45 ± 1 years, Fitzpatrick skin phototypes II-V) to assess skin elasticity, hydration, and mild skin depression correction following cheek area injections.

niacinamidehyaluronic_acidpha
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protocolsRCT

Sunscreen use and the prevention of photoaging: a 4.5-year randomized controlled trial

Annals of Internal Medicine · Jun 2013

A 4.5-year RCT showed daily SPF 15 reduces skin aging by 24% measured objectively. There is no anti-aging serum with this evidence base. Daily SPF is the single highest-leverage intervention.

sunscreenspfphotoaging
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ingredientsSystematic Review

Efficacy and safety of recombinant human epidermal growth factor combined with fractional carbon dioxide laser for facial atrophic acne scars: a systematic review and meta-analysis of randomized trials.

Lasers Med Sci · May 2026

The combination of recombinant human epidermal growth factor (rhEGF) and fractional carbon dioxide (CO2) laser therapy is increasingly used in the treatment of facial atrophic acne scars. This study aimed to systematically assess the efficacy and safety of rhEGF combined with fractional CO2 laser therapy for managing facial atrophic acne scars. PubMed, Embase, the Cochrane Library, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, SinoMed, and VIP were searched from inception to July 29, 2025.

centellaacneaging
Read →
regulationSystematic Review

Applications of bakuchiol in dermatology: Systematic review of the literature.

J Cosmet Dermatol · Dec 2022

Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti-aging, anti-inflammatory, and antibacterial properties. The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient in skincare. Our aim was to review the data for the applications of BAK in dermatology.

retinolbakuchiolacne
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protocolsRCT

Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study.

J Cosmet Dermatol · Jan 2026

Dermocosmetics have proven their benefit in acne management. However, only very few studies investigated their efficacy kinetics. This study assessed the efficacy kinetics of a dermocosmetic cream (DC) containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis in subjects with acne.

niacinamidesalicylic_acidzinc
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Hyperpigmentation Research · 93 studies

Melasma, post-inflammatory hyperpigmentation, sun damage, and what shifts them.

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regulationOpinion

Multitargeted Modulation of Skin Dullness by HNHT Formulation: Synergistic Inhibition of Melanogenesis, Glycation, and Lipofuscin Deposition.

J Cosmet Dermatol · May 2026

Skin dullness, characterized by pigmentation disorders and yellowing, is a major cosmetic concern in Asian populations. Lipofuscin exhibits ultraviolet (UV)/visible light spectral absorption, reduces skin reflectance, and contributes to dullness, whereas existing therapies targeting melanogenesis and glycation lack comprehensive efficacy. This study aimed to evaluate the multimodal anti-dullness effects of a novel formulation (HNHT: hyaluronic acid, niacinamide, hydrolyzed red algae, and tranexamic acid).

niacinamidehyaluronic_acidtranexamic_acid
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ingredientsSystematic Review

Efficacy and safety of recombinant human epidermal growth factor combined with fractional carbon dioxide laser for facial atrophic acne scars: a systematic review and meta-analysis of randomized trials.

Lasers Med Sci · May 2026

The combination of recombinant human epidermal growth factor (rhEGF) and fractional carbon dioxide (CO2) laser therapy is increasingly used in the treatment of facial atrophic acne scars. This study aimed to systematically assess the efficacy and safety of rhEGF combined with fractional CO2 laser therapy for managing facial atrophic acne scars. PubMed, Embase, the Cochrane Library, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, SinoMed, and VIP were searched from inception to July 29, 2025.

centellaacneaging
Read →
ingredientsSystematic Review

L-Carnitine in Dermatology: A Systematic Review of Therapeutic Potential and Biomarker Applications.

J Cutan Med Surg · Mar 2026

L-Carnitine, an amino acid derivative critical for fatty acid metabolism, exhibits anti-inflammatory, antioxidant, and cytoprotective properties, with emerging applications in dermatology. This review explores its therapeutic potential, both topically and systemically, and its role as a biomarker in various skin disorders. A systematic search of Medline, EMBASE, and PubMed (1946-January 2025) was conducted, focusing on L-carnitine and dermatologic conditions, excluding acetyltransferases, acyltransferases, breast, and genetic metabolic diseases.

retinolsalicylic_acidacne
Read →
regulationSystematic Review

Applications of bakuchiol in dermatology: Systematic review of the literature.

J Cosmet Dermatol · Dec 2022

Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti-aging, anti-inflammatory, and antibacterial properties. The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient in skincare. Our aim was to review the data for the applications of BAK in dermatology.

retinolbakuchiolacne
Read →
ingredientsSystematic Review

Iontophoresis-Based Topical Drug Delivery for Dermatologic Conditions: A Systematic Review.

Pharmaceuticals (Basel) · May 2026

The efficacy of topical therapies in dermatology is often limited by the barrier function of the stratum corneum, which restricts drug penetration. Iontophoresis is a non-invasive transdermal delivery technique that uses a low-intensity electrical current to enhance the transport of charged and polar molecules across the skin. It has emerged as a strategy to improve local drug bioavailability while minimizing systemic exposure.

phaacnehyperpigmentation
Read →
ingredientsSystematic Review

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Clinical Interventions in Aging · Mar 2022

Retinol is the gold standard for anti-aging — backed by more research than almost any other skincare ingredient. Starting slowly is key: a progressive introduction cuts irritation by 73%.

retinolretinoidaging
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Barrier & Sensitivity · 92 studies

Stratum corneum, transepidermal water loss, the reactive-skin literature.

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ingredientsRCT

Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.

Photochem Photobiol Sci · May 2026

Nicotinamide (NAM) and Polypodium leucotomos extract (PL) have demonstrated photoprotective effects, but their role in preventing UVA-induced DNA damage in humans remains unclear. To evaluate the effects of oral NAM and PL on UVA-induced erythema and thymidine dimer (TT-dimer) formation. In this intraindividual trial, 50 healthy volunteers (phototypes I-III) were randomized (1:1) to receive either NAM (2000 mg daily) or PL (Heliocare Advanced: 480 mg daily) for 30 days.

niacinamidepharosacea
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protocolsOpinion

Decoding Sensitive Skin Syndrome: International Expert Advisory Insights on Management From India and the United States of America.

J Drugs Dermatol · Jul 2026

Sensitive skin syndrome (SSS) is a common self-reported condition, more prevalent in women, characterized by redness, irritation, and discomfort in response to various triggers. SSS remains a multifactorial condition with overlapping symptoms and no clear correlation between sensory complaints and observable signs, complicating both diagnosis and management. This study aimed to establish expert-driven recommendations for the diagnosis, treatment, and holistic care of SSS.

niacinamidehyaluronic_acidceramides
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regulationSystematic Review

Applications of bakuchiol in dermatology: Systematic review of the literature.

J Cosmet Dermatol · Dec 2022

Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti-aging, anti-inflammatory, and antibacterial properties. The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient in skincare. Our aim was to review the data for the applications of BAK in dermatology.

retinolbakuchiolacne
Read →
ingredientsSystematic Review

Iontophoresis-Based Topical Drug Delivery for Dermatologic Conditions: A Systematic Review.

Pharmaceuticals (Basel) · May 2026

The efficacy of topical therapies in dermatology is often limited by the barrier function of the stratum corneum, which restricts drug penetration. Iontophoresis is a non-invasive transdermal delivery technique that uses a low-intensity electrical current to enhance the transport of charged and polar molecules across the skin. It has emerged as a strategy to improve local drug bioavailability while minimizing systemic exposure.

phaacnehyperpigmentation
Read →
researchSystematic Review

Specialized Pro-Resolving Lipid Mediators and Dietary Omega-3/6 Fatty Acids in Selected Inflammatory Skin Diseases: A Systematic Review.

Antioxidants (Basel) · Dec 2025

Specialized pro-resolving mediators (SPMs), including lipoxins, resolvins, protectins, and maresins, actively terminate inflammation and restore tissue homeostasis. This review addresses how specialized pro-resolving mediators (SPMs) and their omega-3/omega-6 PUFA precursors influence inflammatory pathways, disease mechanisms, and therapeutic potential across major inflammatory skin disorders. MEDLINE/PubMed was searched on 4 October 2025.

acnesensitivityeczema
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ingredientsRCT

Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study.

Sci Rep · Jan 2026

satoko@kao. Skin barrier function impairment and inflammation promote allergen invasion through the skin, leading to sensitization and exacerbation of allergic diseases. Intake of linseed oil, an oil rich in alpha-linolenic acid (ALA), suppresses inflammation and allergic symptoms.

glycerinpharosacea
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Nutrition & Skin · 38 studies

The gut–skin axis, dietary patterns, and supplementation that moves the needle.

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nutritionRCT

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis.

Drug Des Devel Ther · Jan 2026

Rosacea is a chronic inflammatory skin disease with a global prevalence of approximately 5. Existing evidence suggests that its pathogenesis may be associated with dysregulation of the neuro-hormone-immune network within the skin-gut-brain axis framework. This review summarizes the potential roles of stress hormones, sex hormones, and insulin-like growth factor-1 in the four major subtypes.

acnerosacearct
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nutritionSystematic Review

Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Cosmet Dermatol · Mar 2026

Acne vulgaris is one of the most prevalent disorders affecting 9%-10% of the global population, representing as papules, pustules, and comedones, with a pathogenesis involving increased sebum production, C. acnes colonization, and inflammation. Conventional treatments like retinoids and antibiotics often cause side effects, thus diverting attention toward probiotics as an alternative therapy.

retinolglycolic_acidbenzoyl_peroxide
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nutritionSystematic Review

Dietary patterns, metabolic pathways and metainflammation in hidradenitis suppurativa: a systematic review.

Front Immunol · Jan 2026

Dietary factors have been suggested to influence inflammatory skin diseases; however, their role in the pathogenesis and clinical course of hidradenitis suppurativa (HS) remains insufficiently understood. Increasing evidence suggests that HS is a systemic immunometabolic disease characterized by chronic low-grade inflammation and metabolic comorbidities such as obesity, insulin resistance, and metabolic syndrome. Dietary patterns may therefore influence HS activity through metabolic and inflammatory pathways.

zincacnesystematic_review
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nutritionSystematic Review

The Latest Advances in Rosacea Treatment: A Systematic Review.

Pharmaceuticals (Basel) · Jun 2026

Rosacea is a chronic inflammatory dermatosis characterized by vascular dysregulation, immune dysfunction, neurovascular alterations, and microbial involvement. Recent advances in understanding its pathophysiology have led to the development of targeted therapeutic strategies addressing multiple disease mechanisms. This systematic review aimed to evaluate contemporary evidence regarding emerging and established treatment approaches for rosacea.

azelaic_acidpharosacea
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nutritionRCT

Randomized Controlled Study of Bacteriophages in Acne Reveals Efficacy and Novel Mechanism for Promoting Long-Term Skin Health.

J Drugs Dermatol · Jun 2026

Acne is the most prevalent skin disease globally, with a significant burden and limited therapeutic innovation. Although it has a multifactorial etiology, Cutibacterium acnes (C acnes) overgrowth is a key factor in driving inflammation in acne. Bacteriophages are a novel mechanism that can specifically target C acnes and are found in greater abundance on healthy skin compared to acne-prone skin.

salicylic_acidphaacne
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nutritionCohort

The brain-gut-skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies.

Front Immunol · Jan 2026

Emerging evidence suggests that the brain-gut-skin axis (BGSA) plays a critical role in the pathogenesis of inflammatory and disfiguring skin diseases. Conditions such as acne, atopic dermatitis, psoriasis, rosacea, vitiligo, and alopecia areata, once regarded as localized disorders driven mainly by cutaneous immune dysfunction, are now recognized as systemic conditions associated with neuroendocrine stress responses, gut microbial dysbiosis, and chronic low-grade inflammation. Mechanistic studies elucidate the intricate interorgan communication mediated by microbial metabolites (e.

peptidesphaacne
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