RESULTS: Ex vivo results showed that the EGT+CP+NaHA triple combination (TC) attenuated UV-induced epithelial thinning and collagen fiber disruption. Clinically, oral TC to Chinese women improved skin hydration, elasticity, and barrier function, while reducing the number, depth, area, and volume of crow's feet wrinkles, nasolabial folds and marionette lines.
Relevant if you're working with hyaluronic acid, peptides, glycolic acid for aging and dehydration.
If you're targeting aging, this research supports adding hyaluronic_acid to your AM/PM routine.
If you're targeting aging, this research supports adding peptides to your AM/PM routine.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Front Nutr. 2026 Aug 21;13:1888269. doi: 10.3389/fnut.2026.1888269. eCollection 2026. Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis. Zhou Z(1)(2), Zhao L(2), Chen L(2), Zhao X(3), Li X(3), Luo X(4), Zhang B(1), Miao J(3), Liu F(1)(2).
1. Front Nutr. 2026 Aug 21;13:1888269. doi: 10.3389/fnut.2026.1888269. eCollection 2026. Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis. Zhou Z(1)(2), Zhao L(2), Chen L(2), Zhao X(3), Li X(3), Luo X(4), Zhang B(1), Miao J(3), Liu F(1)(2). Author information: (1)Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, Guangzhou, China. (2)China Research and Innovation Center, H&H Research, H&H Group, Guangzhou, China. (3)Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China. (4)School of Food Science and Engineering, South China University of Technology, Guangzhou, China. BACKGROUND: Skin aging involves intrinsic chronological aging and extrinsic photoaging, characterized by impaired barrier function, extracellular matrix (ECM) degradation, and chronic inflammation. METHODS: This study evaluated anti-aging efficacy and mechanisms of ergothioneine (EGT), collagen peptides (CP) and sodium hyaluronate (NaHA) using an ex vivo human skin model and a clinical trial. RESULTS: Ex vivo results showed that the EGT+CP+NaHA triple combination (TC) attenuated UV-induced epithelial thinning and collagen fiber disruption. Mechanistically, TC enhanced antioxidant capacity by up-regulating Nrf2 and SOD2 expression, modulated the senescence-associated secretory phenotype (SASP) via restoring TGF-β1 and suppressing IL-1α, IL-6, and MMP1 levels, and preserved ECM integrity by reversing reductions in collagen I, III, IV, VII, XVII, and hyaluronic acid (HA) contents. Clinically, oral TC to Chinese women improved skin hydration, elasticity, and barrier function, while reducing the number, depth, area, and volume of crow's feet wrinkles, nasolabial folds and marionette lines. CONCLUSION: These findings demonstrate that TC exerts multifaceted anti-aging effects by targeting oxidative stress, inflammatory pathways, and ECM homeostasis, providing a scientific basis for the development of novel oral nutricosmetics for facial skin anti-aging. Copyright © 2026 Zhou, Zhao, Chen, Zhao, Li, Luo, Zhang, Miao and Liu. DOI: 10.3389/fnut.2026.1888269 PMCID: PMC13541516 PMID: 42698538 Conflict of interest statement: ZZ, LC, FL, and LZ were employed by H&H Group. This study received funding from H&H Group. The funder was involved in the study design, the collection, analyses, interpretation of data, the writing of this article and the decision to submit it for publication. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Original source →Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Skin dullness, characterized by pigmentation disorders and yellowing, is a major cosmetic concern in Asian populations. Lipofuscin exhibits ultraviolet (UV)/visible light spectral absorption, reduces skin reflectance, and contributes to dullness, whereas existing therapies targeting melanogenesis and glycation lack comprehensive efficacy. This study aimed to evaluate the multimodal anti-dullness effects of a novel formulation (HNHT: hyaluronic acid, niacinamide, hydrolyzed red algae, and tranexamic acid).
This study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality. These ingredients are increasingly recognized for their synergistic effects in aesthetic medicine, with HA and PN providing hydration and skin support, and niacinamide offering anti-inflammatory and antioxidant properties. A prospective, open-label clinical investigation was conducted on 42 female subjects (mean age 45 ± 1 years, Fitzpatrick skin phototypes II-V) to assess skin elasticity, hydration, and mild skin depression correction following cheek area injections.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →