Snap-8
INCI: Acetyl Octapeptide-3
Also known as: Acetyl Octapeptide-3
PeptidespeptidesyntheticEmerging evidencePregnancy safe
71
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
5%–10%
How It Works
An extended version of Argireline with an additional three amino acids, giving stronger SNARE-complex inhibition and longer-lasting expression-line softening.
Same SNAP-25 N-terminus mimicry as Argireline, but the longer chain has higher SNARE affinity, reducing acetylcholine release more effectively.
pH Range
5.0–7.0
Benefits
- Reduces expression lines
- Longer-acting than Argireline
- Topical tox alternative
Proven For
What the evidence supports.
Expression lines
Best For
- All skin types
Avoid If
No notable contraindications reported.
Layering Order
5/10
Mid-routine serum or treatment step.
Max Safe Concentration
10%
Concentration range in well-formulated products: 5%–10%
Seasonal Use
Year-round.
For Estheticians & Professionals
Stack with Argireline + Leuphasyl for the 'topical-tox trio.'
Pairs Well With
Conflicts With
No flagged conflicts. Still, patch-test new actives.
Your Skin Compatibility
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