Peptides (Argireline)
INCI: Acetyl Hexapeptide-8
Also known as: Argireline, Ac-EEMQRR
PeptidespeptidesyntheticEmerging evidencePregnancy safe
72
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
5%–10%
How It Works
A neurotransmitter-modulating peptide marketed as a topical alternative to botulinum toxin for expression lines.
Mimics the N-terminus of SNAP-25, competing with it in the SNARE complex and dampening acetylcholine release at neuromuscular junctions in the upper dermis.
pH Range
5.0–7.0
Benefits
- Softens expression lines
- Smooths forehead and eye area
- Non-invasive 'tox-like' effect
Proven For
What the evidence supports.
Expression linesCrow's feetForehead lines
Best For
- Mature
- Normal
Avoid If
No notable contraindications reported.
Layering Order
5/10
Mid-routine serum or treatment step.
Max Safe Concentration
10%
Concentration range in well-formulated products: 5%–10%
Seasonal Use
Year-round.
Nutrition Connection
-
Skin Signals When You Need It
- Etched expression lines
For Estheticians & Professionals
Marketing exceeds evidence, useful adjunct, not a tox replacement. Best at 10%.
Notable Research
- Blanes-Mira et al. 2002, 10% Argireline reduced wrinkle depth 30% in 30 days
Pairs Well With
Conflicts With
No flagged conflicts. Still, patch-test new actives.
Your Skin Compatibility
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