Hyaluronic Acid

INCI: Hyaluronic Acid
Also known as: HA, Hyaluronan
HydrationhumectantbiotechStrong evidencePregnancy safe
90
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.1%–2%
How It Works

A polysaccharide naturally found in the dermal matrix; topically it draws water to the skin's surface and plumps fine dehydration lines.

Hydrophilic glycosaminoglycan that binds up to 1,000× its weight in water, hydrating the stratum corneum without occlusion.

pH Range
5.0–8.0
Benefits
  • Hydrates
  • Plumps fine lines
  • Soothes
  • Supports barrier
  • Universally tolerated
Proven For

What the evidence supports.

DehydrationFine linesCompromised barrier
Best For
  • All skin types
Avoid If

No notable contraindications reported.

Layering Order
4/10

Mid-routine serum or treatment step.

Max Safe Concentration
2%

Concentration range in well-formulated products: 0.1%–2%

Seasonal Use

Year-round; in dry climates always seal with emollient to prevent reverse-osmosis dehydration.

Nutrition Connection

Bone broth, soy, root vegetables support endogenous HA synthesis.

Skin Signals When You Need It
  • Dehydration lines
  • Tight feeling skin
For Estheticians & Professionals

Always apply to damp skin and immediately follow with a moisturiser. Dry-on-dry application can backfire.

Notable Research
  • Pavicic et al. 2011, multiweight HA improved skin hydration and elasticity in 8 weeks
Clinical Evidence

The research behind Hyaluronic Acid.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial
Nano-hyaluronic acid significantly improved skin hydration and elasticity after 8 weeks.
Jegasothy SM, Zabolotniaia V, Bielfeldt S
Journal of Clinical and Aesthetic Dermatology, 2014
View Study →
Systematic Review
Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.
Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019
View Study →
Systematic Review
Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.
Wilkinson HN, Hardman MJ
Maturitas, 2017
View Study →
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →
Conflicts With

No flagged conflicts. Still, patch-test new actives.

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The science behind Hyaluronic Acid

1 study from the Intelligence Vault that discuss Hyaluronic Acid.

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