Ceramide NP
The most abundant ceramide in the human stratum corneum; restores the lipid lamellae that hold barrier cells together.
Inserts into the lipid matrix between corneocytes, restoring the lamellar bilayer that retains water and excludes irritants.
- Repairs barrier
- Reduces TEWL
- Calms reactive skin
- Long-term hydration
- Biomimetic
What the evidence supports.
- All skin types
No notable contraindications reported.
Later treatment or moisturiser step.
Concentration range in well-formulated products: 0.1%–2%
Year-round; critical winter ingredient.
Dietary precursors: wheat, rice bran, eggs, dairy.
- Tight, flaky skin
- Reactive barrier
Best ratio: ceramide : cholesterol : fatty acid at 1:1:1 mirrors lamellar membrane structure.
The research behind Ceramide NP.
Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.
Inflammation and Allergy Drug Targets, 2014
Cutis, 2006
Journal of Advanced Research, 2015
Journal of Clinical and Aesthetic Dermatology, 2014
No flagged conflicts. Still, patch-test new actives.
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