Niacinamide
A multitasking B3 derivative that strengthens the skin barrier, regulates sebum, brightens uneven pigmentation, and reduces redness. Among the best-tolerated actives in dermatology.
Acts as a precursor for NAD+/NADP+ co-enzymes, accelerating ceramide synthesis and inhibiting melanosome transfer to keratinocytes. Also down-regulates sebaceous lipid production.
- Strengthens barrier
- Reduces redness
- Minimises pore appearance
- Evens skin tone
- Regulates sebum
What the evidence supports.
- All skin types
- Known niacin allergy
Mid-routine serum or treatment step.
Concentration range in well-formulated products: 2%–10%
Year-round; especially valuable in winter for barrier support.
Dietary niacin: meat, fish, mushrooms, peanuts, fortified grains.
- Pellagra dermatitis (rare)
- Dull tone
- Increased sensitivity
The 'safe upgrade' for nearly every routine. Combine with HA and ceramides for foundational barrier repair.
- Hakozaki et al. 2002, 5% niacinamide reduced hyperpigmentation in 8 weeks
- Bissett et al. 2005, improved fine lines, hyperpigmentation, red blotchiness
The research behind Niacinamide.
Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.
Journal of Cosmetic and Laser Therapy, 2006
British Journal of Dermatology, 2002
International Journal of Dermatology, 2004
International Journal of Dermatology, 1991
No flagged conflicts. Still, patch-test new actives.
Sign up to see how Niacinamide fits your skin archetype and personalised protocol.
3 studies from the Intelligence Vault that discuss Niacinamide.
- rct · J Peripher Nerv SystEvaluation of Nicotinamide Riboside in Prevention of Small Nerve Fiber Axon Degeneration and Promotion of Nerve Regeneration.
- rct · Lancet NeurolSafety and efficacy of individualised exercise and NAD(+) precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial.
- rct · Photochem Photobiol SciChanges in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.