Leuphasyl
INCI: Pentapeptide-18
Also known as: Pentapeptide-18
PeptidespeptidesyntheticEmerging evidencePregnancy safe
70
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
2%–5%
How It Works
A neurotransmitter-targeting peptide that modulates enkephalin signaling at the neuromuscular junction. Used synergistically with Argireline.
Acts as enkephalin agonist on δ-opioid receptors of motor neurons, suppressing acetylcholine release and reducing muscle contraction-driven wrinkles.
pH Range
5.0–7.0
Benefits
- Reduces expression lines
- Synergises with Argireline
- Well-tolerated
Proven For
What the evidence supports.
Expression lines
Best For
- All skin types
Avoid If
No notable contraindications reported.
Layering Order
5/10
Mid-routine serum or treatment step.
Max Safe Concentration
5%
Concentration range in well-formulated products: 2%–5%
Seasonal Use
Year-round.
For Estheticians & Professionals
Pair with Argireline for additive expression-line softening (synergy documented by Lipotec).
Pairs Well With
Conflicts With
No flagged conflicts. Still, patch-test new actives.
Your Skin Compatibility
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