Matrixyl 3000
INCI: Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7
Also known as: Pal-GHK, Pal-GQPR
PeptidespeptidesyntheticModerate evidencePregnancy safe
87
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
3%–10%
How It Works
A dual-peptide complex from Sederma. GHK signals matrix synthesis; GQPR dampens inflammation. Together they target both aging and inflammaging.
Pal-GHK stimulates collagen, GAG, and elastin synthesis; Pal-GQPR inhibits IL-6 and modulates fibroblast inflammation.
pH Range
5.0–7.0
Benefits
- Reduces fine lines
- Smooths skin
- Anti-inflammatory
- Restores firmness
- Synergistic dual action
Proven For
What the evidence supports.
PhotoagingFine linesInflammaging
Best For
- All skin types
Avoid If
No notable contraindications reported.
Layering Order
5/10
Mid-routine serum or treatment step.
Max Safe Concentration
10%
Concentration range in well-formulated products: 3%–10%
Seasonal Use
Year-round.
Nutrition Connection
-
Skin Signals When You Need It
- Crepiness
- Loss of bounce
For Estheticians & Professionals
Premium upgrade from single-peptide Matrixyl. Higher cost is justified by dual-mechanism evidence.
Notable Research
- Sederma in vivo 2003, 8% Matrixyl 3000 improved wrinkle volume 45% in 2 months
Clinical Evidence
The research behind Matrixyl 3000.
Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.
Randomized Controlled Trial
Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.
Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013
View Study →Annals of Internal Medicine, 2013
Systematic Review
Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.
Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019
View Study →Journal of Drugs in Dermatology, 2019
Systematic Review
Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.
Wilkinson HN, Hardman MJ
Maturitas, 2017
View Study →Maturitas, 2017
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →Inflammation and Allergy Drug Targets, 2014
Pairs Well With
Conflicts With
Direct acids (pH < 4)
Your Skin Compatibility
Sign up to see how Matrixyl 3000 fits your skin archetype and personalised protocol.