Allantoin

INCI: Allantoin
Also known as: 5-Ureidohydantoin
SoothingsoothingsyntheticModerate evidencePregnancy safe
75
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.1%–2%
How It Works

A keratolytic and skin-softening agent that calms irritation and accelerates desquamation of damaged cells.

Increases cell proliferation, softens keratin (mild keratolysis), and forms complexes with irritants to neutralise them.

pH Range
4.0–8.0
Benefits
  • Calms irritation
  • Softens skin
  • Supports recovery of minor wounds
  • Universal tolerability
Proven For

What the evidence supports.

SensitivityMinor burnsRough texture
Best For
  • All skin types
Avoid If

No notable contraindications reported.

Layering Order
4/10

Mid-routine serum or treatment step.

Max Safe Concentration
2%

Concentration range in well-formulated products: 0.1%–2%

Seasonal Use

Year-round.

Nutrition Connection

Endogenous metabolite of uric acid.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Inexpensive workhorse soothing ingredient, included in most calming formulas.

Clinical Evidence

The research behind Allantoin.

2 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →
Randomized Controlled Trial
Ceramide-dominant emollients improved skin barrier function by 63% within 6 weeks.
Draelos ZD, Ertel K, Berge C
Cutis, 2006
View Study →
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

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The science behind Allantoin

1 study from the Intelligence Vault that discuss Allantoin.

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