The optimized formulation exhibited nanoscale particle size, high encapsulation efficiency, enhanced skin retention, and improved spreadability. Compared with free mucus, Lipo-mucus significantly increased the epidermal and dermal deposition of total protein and allantoin. Both treatments exerted remarkable anti-aging effects, evidenced by improved skin architecture and enhanced collagen deposition.
Relevant if you're working with allantoin, pha, collagen for aging and dehydration.
If you're targeting aging, this research supports adding allantoin to your AM/PM routine.
If you're targeting aging, this research supports adding pha to your AM/PM routine.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Int J Mol Sci. 2026 Aug 28;27(17):7729. doi: 10.3390/ijms27177729. Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling. Mosalam EM(1)(2), Abdel-Bar HM(3)(4), AbdElhafez AR(5), Ghoneim ME(6), Metwally EM(7), Nofal AE(8), Elberri AI(9).
1. Int J Mol Sci. 2026 Aug 28;27(17):7729. doi: 10.3390/ijms27177729. Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling. Mosalam EM(1)(2), Abdel-Bar HM(3)(4), AbdElhafez AR(5), Ghoneim ME(6), Metwally EM(7), Nofal AE(8), Elberri AI(9). Author information: (1)Biochemistry Department, Faculty of Pharmacy, Menoufia University, Shebin EL-Kom 32511, Menoufia, Egypt. (2)Department of Pharm D, Faculty of Pharmacy, Jadara University, Irbid 21110, Jordan. (3)Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University (DMU), Leicester LE19BH, UK. (4)Department of Pharmaceutics, Faculty of Pharmacy, University of Sadat City (USC), Sadat City 32897, Menofia Governorate, Egypt. (5)Invertebrates Division, Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt. (6)Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City (USC), Sadat City 32897, Menofia Governorate, Egypt. (7)Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt. (8)Histology and Histochemistry Division, Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt. (9)Genetic Engineering and Molecular Biology Division, Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt. Chronological skin aging is a complex biological process characterized by progressive collagen degradation and cellular senescence. Among the molecular regulators implicated in these hallmarks, miR-34a has emerged as a critical mediator linking inflammation and senescence pathways. Consequently, this study aimed to investigate the anti-aging potential of Helix aspersa snail mucus, with particular emphasis on its modulation of miR-34a-associated molecular mechanisms, and to explore liposomal encapsulation as a strategy to improve its topical performance and user acceptability. Snail mucus was collected and characterized using LC-ESI-QTOF-MS/MS, while its antioxidant activity was assessed by DPPH and FRAP assays. Afterward, mucus-loaded liposomes were developed and optimized. Aged mice were assigned to control aged, Lipo, free mucus, and Lipo-mucus groups, alongside a young control group. Anti-aging efficacy was evaluated through wrinkle grading, skin moisture determination, histological examination, and collagen assessment by Masson's trichome staining. miR-34a-5p, its target genes, and related aging-associated genes were also determined, followed by upstream regulatory network prediction using X2Kweb. The optimized formulation exhibited nanoscale particle size, high encapsulation efficiency, enhanced skin retention, and improved spreadability. Compared with free mucus, Lipo-mucus significantly increased the epidermal and dermal deposition of total protein and allantoin. Both treatments exerted remarkable anti-aging effects, evidenced by improved skin architecture and enhanced collagen deposition. These effects were associated with modulation of the miR-34a-5p-driven senescence hub. Collectively, liposomal encapsulation enhanced the cutaneous delivery, cosmetic properties, and anti-aging efficacy of H. aspersa mucus, supporting its potential as a mechanism-based cosmeceutical intervention for chronological skin aging. DOI: 10.3390/ijms27177729 PMCID: PMC13566471 PMID: 42737625 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
Original source →Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early clinical studies, on cardiopulmonary fitness in individuals with Friedreich's ataxia. This 12-week, outpatient, phase 2, single-site (Children's Hospital of Philadelphia, Philadelphia, PA, USA), randomised, 2 × 2 factorial clinical trial recruited individuals aged 10-40 years with an ejection fraction of 45% or greater who were able to exercise.
Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →