Vitamin C (Ascorbyl Glucoside)

INCI: Ascorbyl Glucoside

Also known as: AA2G, Glucoside Vitamin C

Vitamin CantioxidantsyntheticModerate evidencePregnancy safe

Skinlumis Rating

Comedogenic

0/5

Irritancy

1/5

Best applied

Both

Effective range

2%–5%

How It Works

A stable, water-soluble Vitamin C derivative that converts gradually to L-ascorbic acid in the skin via alpha-glucosidase. Far gentler than LAA, suitable for sensitive skin.

Skin alpha-glucosidase slowly hydrolyses the glucose group, releasing free ascorbic acid for tyrosinase inhibition and antioxidant action over hours.

pH Range

5.0–7.0

Benefits

Stable Vitamin C
Gentle brightening
Antioxidant
Suitable for sensitive skin
AM/PM compatible

Proven For

What the evidence supports.

HyperpigmentationDullnessMild photoaging

Best For

Sensitive
Dry
Normal
Reactive

Avoid If

No notable contraindications reported.

Layering Order

4/10

Mid-routine serum or treatment step.

Max Safe Concentration

Concentration range in well-formulated products: 2%–5%

Seasonal Use

Year-round.

Nutrition Connection

Same precursor as LAA, citrus and leafy greens.

Skin Signals When You Need It

Mild dullness
Slow brightening response

For Estheticians & Professionals

Ideal gateway Vitamin C for clients who can't tolerate LAA's low pH.

Notable Research

Yamamoto et al. 1990, sustained ascorbic acid release in skin over 24 hours

Clinical Evidence

The research behind Vitamin C (Ascorbyl Glucoside).

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial

Vitamin C showed comparable efficacy to hydroquinone for melasma treatment.

Espinal-Perez LE, Moncada B, Castanedo-Cazares JP
International Journal of Dermatology, 2004

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Randomized Controlled Trial

Niacinamide inhibits melanosome transfer to keratinocytes, reducing hyperpigmentation by up to 35%.

Hakozaki T, Minwalla L, Zhuang J et al.
British Journal of Dermatology, 2002

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Randomized Controlled Trial

Azelaic acid comparable to hydroquinone for hyperpigmentation with superior safety across all Fitzpatrick types.

Balina LM, Graupe K
International Journal of Dermatology, 1991

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Systematic Review

Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.

Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019

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Pairs Well With

Niacinamide Hyaluronic Acid Peptides (Matrixyl)

Conflicts With

Strong acids (pH < 4)

Your Skin Compatibility