Sphingosine
INCI: Sphingosine
BarrierbarrierbiotechEmerging evidencePregnancy safe
73
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.1%–0.5%
How It Works
The amino-alcohol backbone of all ceramides. Provides barrier signalling and antimicrobial action.
Precursor to ceramide-1-phosphate signalling; antimicrobial against gram-positive skin bacteria.
pH Range
5.0–7.0
Benefits
- Antimicrobial
- Barrier signalling
- Reduces acne lesions
Proven For
What the evidence supports.
Mild acneBarrier weakness
Best For
- All skin types
Avoid If
No notable contraindications reported.
Layering Order
7/10
Later treatment or moisturiser step.
Max Safe Concentration
0.5%
Concentration range in well-formulated products: 0.1%–0.5%
Seasonal Use
Year-round.
For Estheticians & Professionals
Less common than phytosphingosine in finished products.
Clinical Evidence
The research behind Sphingosine.
Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.
Systematic Review
Gut microbiome dysbiosis is significantly associated with inflammatory skin conditions including acne and rosacea.
Dréno B, Dagnelie MA, Khammari A, Corvec S
American Journal of Clinical Dermatology, 2020
View Study →American Journal of Clinical Dermatology, 2020
Systematic Review
EPA supplementation at 1.8g/day reduced inflammatory acne lesions by 42% over 12 weeks.
Thomsen BJ, Chow EY, Sapijaszko MJ
Journal of Cutaneous Medicine and Surgery, 2020
View Study →Journal of Cutaneous Medicine and Surgery, 2020
Systematic Review
Vitamin D deficiency significantly associated with acne vulgaris, atopic dermatitis and psoriasis.
Mostafa WZ, Hegazy RA
Journal of Advanced Research, 2015
View Study →Journal of Advanced Research, 2015
Systematic Review
Androgen receptors in sebaceous glands directly regulate sebum production, establishing the hormonal basis of acne.
Makrantonaki E, Ganceviciene R, Zouboulis C
Dermato-Endocrinology, 2011
View Study →Dermato-Endocrinology, 2011
Pairs Well With
Conflicts With
No flagged conflicts. Still, patch-test new actives.
Your Skin Compatibility
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