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Polyhydroxy Acids (PHA)

INCI: Polyhydroxy Acids
Also known as: PHA, Next-gen acids
ExfoliantsexfoliantbiotechModerate evidencePregnancy safe
81
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
4%–10%
How It Works

Next-generation exfoliants with larger molecules and antioxidant side groups. Almost no irritation, even for rosacea-prone skin. Includes gluconolactone and lactobionic acid.

Multiple hydroxyl groups slow penetration and act as humectants and antioxidants. Exfoliate via the same desmosomal-weakening mechanism as AHAs.

pH Range
3.5–5.0
Benefits
  • Ultra-gentle exfoliation
  • Hydrates
  • Antioxidant
  • Suitable for rosacea
  • Strengthens barrier
Proven For

What the evidence supports.

Sensitive skinRosaceaMild dullness
Best For
  • Sensitive
  • Rosacea-prone
  • Reactive
Avoid If

No notable contraindications reported.

Layering Order
3/10

Apply early in routine, toner/essence step.

Max Safe Concentration
10%

Concentration range in well-formulated products: 4%–10%

Seasonal Use

Year-round.

Nutrition Connection

Gluconolactone derived from glucose fermentation; lactobionic from lactose.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

First-line resurfacing acid for rosacea and sensitive aging skin.

Clinical Evidence

The research behind Polyhydroxy Acids (PHA).

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review
Gut microbiome dysbiosis is significantly associated with inflammatory skin conditions including acne and rosacea.
Dréno B, Dagnelie MA, Khammari A, Corvec S
American Journal of Clinical Dermatology, 2020
View Study →
Randomized Controlled Trial
Lactobacillus supplementation reduced acne lesion count by 48% over 12 weeks.
Bowe W, Patel NB, Logan AC
Beneficial Microbes, 2014
View Study →
Systematic Review
Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.
Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019
View Study →
Systematic Review
Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.
Wilkinson HN, Hardman MJ
Maturitas, 2017
View Study →
Pairs Well With
NiacinamideHyaluronic AcidCentella Asiatica
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

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