Lactobacillus Ferment Lysate

INCI: Lactobacillus Ferment Lysate

Also known as: Probiotic lysate

AdvancedsoothingbiotechEmerging evidencePregnancy safe

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

1%–10%

How It Works

A probiotic-derived lysate that supports the skin microbiome and immune homeostasis.

Microbial metabolites prime Toll-like receptor signalling toward tolerance, calming reactive immunity.

pH Range

4.0–6.0

Benefits

Microbiome support
Anti-inflammatory
Hydrating

Proven For

What the evidence supports.

Sensitive skinRosaceaAtopic skin

Best For

All skin types

Avoid If

No notable contraindications reported.

Layering Order

2/10

Apply early in routine, toner/essence step.

Max Safe Concentration

10%

Concentration range in well-formulated products: 1%–10%

Seasonal Use

Year-round.

Nutrition Connection

Fermented dairy supports gut Lactobacillus.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Pair with oral probiotics for skin-gut axis benefits.

Clinical Evidence

The research behind Lactobacillus Ferment Lysate.

2 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review

Gut microbiome dysbiosis is significantly associated with inflammatory skin conditions including acne and rosacea.

Dréno B, Dagnelie MA, Khammari A, Corvec S
American Journal of Clinical Dermatology, 2020

View Study →

Randomized Controlled Trial

Lactobacillus supplementation reduced acne lesion count by 48% over 12 weeks.

Bowe W, Patel NB, Logan AC
Beneficial Microbes, 2014

View Study →

Pairs Well With

Bifida Ferment Lysate Hyaluronic Acid

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility