Bifida Ferment Lysate

INCI: Bifida Ferment Lysate

Also known as: Probiotic ferment

AdvancedsoothingbiotechEmerging evidencePregnancy safe

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

1%–10%

How It Works

A lysate of Bifidobacterium fermentation that supports skin's repair pathways. Famously used in Lancôme's Génifique.

Microbial metabolites prime keratinocyte DNA-repair enzymes (XPA, XPC) and modulate inflammation.

pH Range

4.0–6.0

Benefits

DNA repair support
Anti-inflammatory
Brightens
Strengthens barrier

Proven For

What the evidence supports.

PhotoagingSensitivityDullness

Best For

All skin types

Avoid If

No notable contraindications reported.

Layering Order

2/10

Apply early in routine, toner/essence step.

Max Safe Concentration

10%

Concentration range in well-formulated products: 1%–10%

Seasonal Use

Year-round.

Nutrition Connection

Yogurt, kefir, fermented foods support gut Bifidobacterium.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Pair with prebiotic ingredients (oat β-glucan) for skin-microbiome support.

Clinical Evidence

The research behind Bifida Ferment Lysate.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial

Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.

Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013

View Study →

Systematic Review

Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.

Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014

View Study →

Randomized Controlled Trial

Ceramide-dominant emollients improved skin barrier function by 63% within 6 weeks.

Draelos ZD, Ertel K, Berge C
Cutis, 2006

View Study →

Systematic Review

Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.

Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019

View Study →

Pairs Well With

Hyaluronic Acid NiacinamidePeptides

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility