Gluconolactone

INCI: Gluconolactone

Also known as: PHA, D-Glucono-1,5-lactone

ExfoliantsexfoliantbiotechModerate evidencePregnancy safe

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

4%–8%

How It Works

A specific PHA derived from glucose fermentation. Famous for its inclusion in NeoStrata's PHA range; tolerated even by post-procedure skin.

Slow surface exfoliation with concurrent moisture binding; chelates iron to dampen oxidative stress.

pH Range

3.5–5.0

Benefits

Gentle resurfacing
Hydrating
Antioxidant
Post-procedure friendly

Proven For

What the evidence supports.

Sensitive agingPost-laser care

Best For

Sensitive
Reactive
Post-procedure

Avoid If

No notable contraindications reported.

Layering Order

3/10

Apply early in routine, toner/essence step.

Max Safe Concentration

10%

Concentration range in well-formulated products: 4%–8%

Seasonal Use

Year-round.

Nutrition Connection

Produced via glucose fermentation.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Ideal first 48–72 hours after laser or microneedling.

Clinical Evidence

The research behind Gluconolactone.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review

Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.

Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019

View Study →

Systematic Review

Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.

Wilkinson HN, Hardman MJ
Maturitas, 2017

View Study →

Systematic Review

Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.

Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014

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Randomized Controlled Trial

Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.

Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013

View Study →

Pairs Well With

Niacinamide Centella Asiatica Hyaluronic Acid

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility