EGF (Epidermal Growth Factor)

INCI: sh-Oligopeptide-1

Also known as: EGF, sh-Oligopeptide-1

AdvancedpeptidebiotechEmerging evidenceNot for pregnancy

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

0.0001%–0.01%

How It Works

A recombinant 53-amino-acid polypeptide that triggers keratinocyte proliferation and migration, the same factor that drives wound healing.

Binds EGFR receptors on keratinocytes, activating MAPK and PI3K/Akt pathways to drive cell division, migration, and survival.

pH Range

5.0–7.0

Benefits

Accelerates healing
Smooths wrinkles
Improves elasticity
Brightens

Proven For

What the evidence supports.

Post-procedurePhotoagingWound healing

Best For

Mature
Normal
Post-procedure

Avoid If

History of skin cancer (consult MD)
Active malignancy

Layering Order

5/10

Mid-routine serum or treatment step.

Max Safe Concentration

0.01%

Concentration range in well-formulated products: 0.0001%–0.01%

Seasonal Use

Year-round.

Nutrition Connection

Skin Signals When You Need It

Slow wound healing

For Estheticians & Professionals

Concerns about pro-mitotic action in malignancy contexts, screen clients carefully.

Clinical Evidence

The research behind EGF (Epidermal Growth Factor).

1 peer-reviewed study

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial

Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.

Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013

View Study →

Pairs Well With

Peptides (Matrixyl)Hyaluronic Acid Niacinamide

Conflicts With

Direct acids (pH < 4)

Your Skin Compatibility