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Adenosine

INCI: Adenosine
Also known as: 9-β-D-Ribofuranosyladenine
PeptidespeptidesyntheticModerate evidencePregnancy safe
80
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.04%–0.1%
How It Works

An endogenous nucleoside that signals dermal fibroblasts to produce more collagen, well-tolerated even at high concentrations.

Activates A2A receptors on fibroblasts, stimulating collagen and elastin synthesis. Modulates inflammatory cytokines.

pH Range
5.0–7.0
Benefits
  • Smooths wrinkles
  • Soothes
  • Boosts collagen
  • Universally tolerated
Proven For

What the evidence supports.

Fine linesPhotoagingSensitivity
Best For
  • All skin types
  • Mature
  • Sensitive
Avoid If

No notable contraindications reported.

Layering Order
5/10

Mid-routine serum or treatment step.

Max Safe Concentration
0.1%

Concentration range in well-formulated products: 0.04%–0.1%

Seasonal Use

Year-round.

Nutrition Connection

Endogenous metabolite of ATP.

Skin Signals When You Need It
  • Slow recovery
For Estheticians & Professionals

Adenosine-rich serums are a Korean MFDS-approved anti-aging staple.

Clinical Evidence

The research behind Adenosine.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review
Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.
Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019
View Study →
Systematic Review
Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.
Wilkinson HN, Hardman MJ
Maturitas, 2017
View Study →
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →
Randomized Controlled Trial
Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.
Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013
View Study →
Pairs Well With
Peptides (Matrixyl)NiacinamideHyaluronic Acid
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

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