High-concentration linoleic acid significantly improved barrier function, as evidenced by reduced testosterone permeability, and enhanced incorporation into phospholipids, triacylglycerols, and diacylglycerols. Unexpectedly, ω-hydroxy-sphingosine ceramide proportions were reduced, reflective of downregulation of key enzymes in ω-O-acylceramide synthesis. This research reveal a complex interplay between linoleic acid availability, lipid remodeling, and enzymatic regulation, offering new insights into optimizing reconstructed skin models for improved barrier function and lipid homeostasis.
Relevant if your routine includes ceramides, glycerin, pha.
This research supports adding ceramides to your AM/PM routine.
This research supports adding glycerin to your AM/PM routine.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Front Physiol. 2026 Jun 22;17:1838020. doi: 10.3389/fphys.2026.1838020. eCollection 2026. Linoleic acid concentration at the air-liquid interface is key for optimal incorporation into skin model lipidome. Tremblay A(1)(2)(3), Larouche A(1)(2)(3), Simard M(1)(2)(3), Dumais É(4), Julien P(5), Flamand N(4), Pouliot R(1)(2)(3).
1. Front Physiol. 2026 Jun 22;17:1838020. doi: 10.3389/fphys.2026.1838020. eCollection 2026. Linoleic acid concentration at the air-liquid interface is key for optimal incorporation into skin model lipidome. Tremblay A(1)(2)(3), Larouche A(1)(2)(3), Simard M(1)(2)(3), Dumais É(4), Julien P(5), Flamand N(4), Pouliot R(1)(2)(3). Author information: (1)Faculté de pharmacie, Université Laval, Québec, QC, Canada. (2)Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada. (3)Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, QC, Canada. (4)Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Département de médecine, Faculté de médecine, Université Laval, Québec, QC, Canada. (5)Axe d'Endocrinologie et de Néphrologie, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada. Linoleic acid is an essential fatty acid required for skin barrier formation. However, linoleic acid-deficient media remains widely used in cell culture and reconstructed skin production, potentially contributing to suboptimal barrier function in skin models. In this study, we investigated the effects of varying linoleic acid concentrations in culture media on lipid composition, bioactive lipid mediator production, and gene expression of lipid-metabolizing enzymes in self-assembled skin substitutes. High-concentration linoleic acid significantly improved barrier function, as evidenced by reduced testosterone permeability, and enhanced incorporation into phospholipids, triacylglycerols, and diacylglycerols. Unexpectedly, ω-hydroxy-sphingosine ceramide proportions were reduced, reflective of downregulation of key enzymes in ω-O-acylceramide synthesis. These findings reveal a complex interplay between linoleic acid availability, lipid remodeling, and enzymatic regulation, offering new insights into optimizing reconstructed skin models for improved barrier function and lipid homeostasis. Copyright © 2026 Tremblay, Larouche, Simard, Dumais, Julien, Flamand and Pouliot. DOI: 10.3389/fphys.2026.1838020 PMCID: PMC13334480 PMID: 42441238 Conflict of interest statement: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Original source →Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early clinical studies, on cardiopulmonary fitness in individuals with Friedreich's ataxia. This 12-week, outpatient, phase 2, single-site (Children's Hospital of Philadelphia, Philadelphia, PA, USA), randomised, 2 × 2 factorial clinical trial recruited individuals aged 10-40 years with an ejection fraction of 45% or greater who were able to exercise.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →