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ingredientsSystematic Review1 min read
Vitamin C in dermatology: mechanisms of action and clinical applications
Authors · Pullar JM, Carr AC, Vissers MCM
Journal · Nutrients · July 2022
What this means for you
The plain-language read
Clinical studies demonstrate L-ascorbic acid at 15-20% concentrations significantly reduces hyperpigmentation through inhibition of tyrosinase.
Key findings
- L-ascorbic acid at 15-20% significantly reduces hyperpigmentation
- Essential cofactor for collagen synthesis
- Vitamin C + Vitamin E = 4x synergistic photoprotection
- Most effective in AM routine before SPF application
Practical note
Use 15-20% L-ascorbic acid in the morning before SPF. Store in dark bottle — oxidizes in light. Pairs synergistically with Vitamin E and ferulic acid for enhanced stability and efficacy.
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What this means for your routine
vitamin_cAM/PM routine15–20%
If you're targeting hyperpigmentation, this research supports adding vitamin_c to your AM/PM routine. Effective concentration range: 15–20% based on this study.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
Technical Summary, For Professional Reference
Clinical context
Vitamin C (ascorbic acid) plays crucial roles in skin health through multiple mechanisms. As the most abundant antioxidant in skin, it protects against photooxidative damage. It is an essential cofactor for collagen synthesis, with deficiency directly impairing wound healing.
Ingredients discussed
Full abstract→
Vitamin C (ascorbic acid) plays crucial roles in skin health through multiple mechanisms. As the most abundant antioxidant in skin, it protects against photooxidative damage. It is an essential cofactor for collagen synthesis, with deficiency directly impairing wound healing. Clinical studies demonstrate L-ascorbic acid at 15-20% concentrations significantly reduces hyperpigmentation through inhibition of tyrosinase. Combination with vitamin E provides synergistic photoprotection 4x greater than either alone.
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