This review showed that grape seed and red grape extracts inhibited the growth of MCF-7 and MDA-MB-231 breast cancer cells. In hypertensive rats, systolic blood pressure decreased from greater than 200 mmHg to less than 150 mmHg. Resveratrol-enriched grape seed oil improved adipose tissue function, enhanced glucose tolerance, and reduced inflammatory markers.
Relevant if you're working with glycolic acid, resveratrol, pha for aging.
If you're targeting aging, this research supports adding glycolic_acid to your AM/PM routine.
If you're targeting aging, this research supports adding resveratrol to your AM/PM routine.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Mol Nutr Food Res. 2026 Oct;70(19):e70626. doi: 10.1002/mnfr.70626. Phytopharmacological and Functional Insights Into the Bioactive Compounds of Grape (Vitis vinifera L.): An Integrated Review of In Vitro, In Vivo, and Clinical Studies. Bereda G(1), Ahamad J(2), Awla SS(2).
1. Mol Nutr Food Res. 2026 Oct;70(19):e70626. doi: 10.1002/mnfr.70626. Phytopharmacological and Functional Insights Into the Bioactive Compounds of Grape (Vitis vinifera L.): An Integrated Review of In Vitro, In Vivo, and Clinical Studies. Bereda G(1), Ahamad J(2), Awla SS(2). Author information: (1)Department of Pharmacy, Marie Stopes International Ethiopia (MSIE), Ambo, Ethiopia. (2)Department of Pharmacognosy, Faculty of Pharmacy, Tishk International University, Erbil, Iraq. Grapes (Vitis vinifera L.) are abundant in polyphenols, flavonoids, and other bioactive constituents. They exhibit a wide range of health-promoting properties, including antioxidant, anti-inflammatory, anticancer, cardioprotective, antidiabetic, and skin anti-aging effects. We review and summarize the phytopharmacological and functional effects of grape-derived compounds. This review includes in vitro, in vivo, and clinical studies. The search combined the terms "V. vinifera" OR "grape" with keywords related to traditional uses, phytochemistry, and pharmacological activities. Peer-reviewed English-language studies published between 2000 and 2025 reporting ethnobotanical uses, phytochemical composition, or pharmacological effects were included. The findings were synthesized qualitatively. This review showed that grape seed and red grape extracts inhibited the growth of MCF-7 and MDA-MB-231 breast cancer cells. Leaf and seed extracts reduced blood glucose in diabetic models, with antioxidant activity IC50 values ranging from 35-41 µg/mL. Biogenic carbon quantum dots derived from V. vinifera enhanced glucose uptake and inhibited α-glucosidase and α-amylase. In hypertensive rats, systolic blood pressure decreased from greater than 200 mmHg to less than 150 mmHg. Resveratrol-enriched grape seed oil improved adipose tissue function, enhanced glucose tolerance, and reduced inflammatory markers. Future research should prioritize standardized extracts, optimized dosing strategies, and robust clinical trials to validate their translational potential. © 2026 Wiley‐VCH GmbH. DOI: 10.1002/mnfr.70626 PMID: 42860878 [Indexed for MEDLINE]
Original source →Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early clinical studies, on cardiopulmonary fitness in individuals with Friedreich's ataxia. This 12-week, outpatient, phase 2, single-site (Children's Hospital of Philadelphia, Philadelphia, PA, USA), randomised, 2 × 2 factorial clinical trial recruited individuals aged 10-40 years with an ejection fraction of 45% or greater who were able to exercise.
Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →