This research assesses the effectiveness of the REGENMEDIC cream (anti-aging cream) and REGENMEDIC serum (anti-aging serum) in promoting skin barrier recovery and enhancing anti-aging effects following PicoWay laser treatment. After 112-day use of REGENMEDIC cream and serum, test group showed increased skin elasticity and firmness, reduced wrinkles, and an overall improvement in skin tone and texture.
Relevant if you're working with niacinamide, panthenol, pha for aging and dehydration.
If you're targeting aging, this research supports adding niacinamide to your AM/PM routine. Timeline to expect: 2 weeks based on study duration.
If you're targeting aging, this research supports adding panthenol to your AM/PM routine. Timeline to expect: 2 weeks based on study duration.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Lasers Med Sci. 2026 Sep 3;41(1):212. doi: 10.1007/s10103-026-04995-1. Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study. Liu H(1), Li B(2), He X(2), Li R(1), Mi R(1), Zhao C(1)(3), Ye C(1), Wang W(2), Wang H(2), Zhu Z(2), Zhou X(2), Hsu K(2), Steel A(3), Qiu J(2), Yi Y(2), Niu Y(2), Huguet C(4), Xiong W(4), Beguin V(4), Kerob D(5), Zheng Y(6)(7).
1. Lasers Med Sci. 2026 Sep 3;41(1):212. doi: 10.1007/s10103-026-04995-1. Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study. Liu H(1), Li B(2), He X(2), Li R(1), Mi R(1), Zhao C(1)(3), Ye C(1), Wang W(2), Wang H(2), Zhu Z(2), Zhou X(2), Hsu K(2), Steel A(3), Qiu J(2), Yi Y(2), Niu Y(2), Huguet C(4), Xiong W(4), Beguin V(4), Kerob D(5), Zheng Y(6)(7). Author information: (1)Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. (2)Research and Innovation Center, L'Oréal China, Shanghai, China. (3)La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. (4)North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China. (5)La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France, France. (6)La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. Zhengyijie20171@outlook.com. (7)Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. Zhengyijie20171@outlook.com. Pro-Xylane is a potent anti-aging ingredient; however, there is limited knowledge regarding whether a comprehensive post-procedure regimen incorporating a combination of Pro-Xylane, niacinamide, and panthenol alongside other active agents can deliver synergistic benefits for both skin barrier repair and anti-aging. This study assesses the effectiveness of the REGENMEDIC cream (anti-aging cream) and REGENMEDIC serum (anti-aging serum) in promoting skin barrier recovery and enhancing anti-aging effects following PicoWay laser treatment. A 112-day randomized controlled trial was conducted with 88 Chinese females, who were divided into two groups: the test group, using REGENMEDIC cream and Serum following PicoWay laser treatment, and the control group, using standard care regimen consisting of a standard cream. Skin barrier-repairing effects were assessed during the initial 14 days following a single use of REGENMEDIC cream, while skin elasticity, firmness, wrinkles and skin tone were evaluated over the 112-day study period after the combined use of REGENMEDIC cream and Serum. The test group exhibited lower transepidermal water loss (TEWL) and higher hydration after 14 days compared to the control group, along with a more significant reduction in skin redness. After 112-day use of REGENMEDIC cream and serum, test group showed increased skin elasticity and firmness, reduced wrinkles, and an overall improvement in skin tone and texture. Dermatologists reported excellent tolerability, with minimal adverse events. Initial application of the REGENMEDIC cream facilitated rapid skin barrier repair, while the subsequent sequential regimen incorporating the serum yielded significant long-term anti-aging benefits following PicoWay laser treatment. This study demonstrates that targeting multiple physiological pathways-specifically hydration, barrier integrity, and cellular senescence-provides a robust therapeutic option for amplifying the anti-aging outcomes of aesthetic procedures. © 2026. The Author(s). DOI: 10.1007/s10103-026-04995-1 PMCID: PMC13538206 PMID: 42686896 [Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: This study was approved by the SGS Ethics Committee for Clinical Research, SGS-CSTC Standards Technical Services (Shanghai) Co., Ltd. (reference number: QDCPCH24000110; ethics approval No. 2024005). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent to participate was obtained from all participants before enrollment. All participants were fully informed about the study procedures, their rights, confidentiality protection, and their right to withdraw from the study at any time. Consent for publication: Written consent for the publication of anonymized study-related information and images was obtained from all participants. No personally identifiable information is presented in this manuscript. Clinical trial registration: This study was designed as an efficacy evaluation of topically applied dermocosmetic formulations following a standard aesthetic procedure, rather than an interventional clinical trial investigating a novel pharmacological agent or medical device. Consequently, formal registration in a public clinical trial database was not mandated by local regulatory guidelines for cosmetic evaluation studies. Nevertheless, the study protocol was conducted under the oversight and prior approval of an independent ethics committee to ensure participant safety and scientific rigor. Competing interests: L’Oréal Dermatological Beauty China, La Roche Posay.
Original source →Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early clinical studies, on cardiopulmonary fitness in individuals with Friedreich's ataxia. This 12-week, outpatient, phase 2, single-site (Children's Hospital of Philadelphia, Philadelphia, PA, USA), randomised, 2 × 2 factorial clinical trial recruited individuals aged 10-40 years with an ejection fraction of 45% or greater who were able to exercise.
Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →