Compared with placebo oil intake, ALA-DAG intake increased skin hydration in the cheek, reduced nasal congestion and nose itchiness, and decreased mite-specific immunoglobulin E in the blood. Subgroup analysis showed that participants who were positive for mite allergen sensitization had reduced facial redness after ingesting ALA-DAG.
Relevant if you're working with glycerin, pha for rosacea and dehydration.
If you're targeting rosacea, this research supports adding glycerin to your AM/PM routine. Timeline to expect: 8 weeks based on study duration.
If you're targeting rosacea, this research supports adding pha to your AM/PM routine. Timeline to expect: 8 weeks based on study duration.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Sci Rep. 2026 Jan 6;16(1):4785. doi: 10.1038/s41598-025-34887-3. Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study. Fukagawa S(1)(2), Shimotoyodome Y(3), Sayama K(4)(5), Sasaki A(3), Saito K(3), Fujita H(5), Shimizu Y(3), Misawa K(3), Saito S(3), Ishikawa J(4)(5), Ota N(5), Yokomizo T(4), Hibi M(3).
1. Sci Rep. 2026 Jan 6;16(1):4785. doi: 10.1038/s41598-025-34887-3. Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study. Fukagawa S(1)(2), Shimotoyodome Y(3), Sayama K(4)(5), Sasaki A(3), Saito K(3), Fujita H(5), Shimizu Y(3), Misawa K(3), Saito S(3), Ishikawa J(4)(5), Ota N(5), Yokomizo T(4), Hibi M(3). Author information: (1)Human Health Care Products Research, Kao Corporation, Bunka 2-1-3, Sumida, Tokyo, 131-8501, Japan. fukagawa.satoko@kao.com. (2)Department of Biochemistry, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo, Tokyo, 113-8421, Japan. fukagawa.satoko@kao.com. (3)Human Health Care Products Research, Kao Corporation, Bunka 2-1-3, Sumida, Tokyo, 131-8501, Japan. (4)Department of Biochemistry, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo, Tokyo, 113-8421, Japan. (5)Biological Science Research, Kao Corporation, Akabane 2606, Ichikai-Machi, Haga-Gun, Tochigi, 321-3497, Japan. Skin barrier function impairment and inflammation promote allergen invasion through the skin, leading to sensitization and exacerbation of allergic diseases. Intake of linseed oil, an oil rich in alpha-linolenic acid (ALA), suppresses inflammation and allergic symptoms. To our knowledge, the effects of diacylglycerol-enriched ALA (ALA-DAG) oil intake on skin properties and allergic symptoms have not been evaluated. We performed a double-blind, randomized, placebo-controlled, parallel-group study of 60 individuals aged 20-59 years with mild skin discomfort, including dryness, itching, and redness, to investigate the effects of ALA-DAG intake on skin and allergic symptoms. Participants were divided into two groups treated with either 2.5 g/day of ALA-DAG or placebo oil for 8 weeks. The skin properties were measured at baseline and at 8 weeks. Allergic symptoms were measured at 4 and 8 weeks. Compared with placebo oil intake, ALA-DAG intake increased skin hydration in the cheek, reduced nasal congestion and nose itchiness, and decreased mite-specific immunoglobulin E in the blood. Subgroup analysis showed that participants who were positive for mite allergen sensitization had reduced facial redness after ingesting ALA-DAG. These findings suggest that ALA-DAG intake improves skin properties and alleviates allergic symptoms. © 2026. The Author(s). DOI: 10.1038/s41598-025-34887-3 PMCID: PMC12873180 PMID: 41495414 [Indexed for MEDLINE] Conflict of interest statement: Declarations. Competing interests: The authors declare no competing interests.
Original source →Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
Nicotinamide (NAM) and Polypodium leucotomos extract (PL) have demonstrated photoprotective effects, but their role in preventing UVA-induced DNA damage in humans remains unclear. To evaluate the effects of oral NAM and PL on UVA-induced erythema and thymidine dimer (TT-dimer) formation. In this intraindividual trial, 50 healthy volunteers (phototypes I-III) were randomized (1:1) to receive either NAM (2000 mg daily) or PL (Heliocare Advanced: 480 mg daily) for 30 days.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →