BACKGROUND: Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. RESULTS: Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds.
Relevant if you're working with retinol, bakuchiol for aging and hyperpigmentation.
If you're targeting aging, this research supports adding retinol to your PM routine. Effective concentration range: 5% based on this study. Timeline to expect: 12 weeks based on study duration.
If you're targeting aging, this research supports adding bakuchiol to your PM routine. Effective concentration range: 5% based on this study. Timeline to expect: 12 weeks based on study duration.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. Br J Dermatol. 2019 Feb;180(2):289-296. doi: 10.1111/bjd.16918. Epub 2018 Sep 21. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.
1. Br J Dermatol. 2019 Feb;180(2):289-296. doi: 10.1111/bjd.16918. Epub 2018 Sep 21. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. Dhaliwal S(1), Rybak I(1), Ellis SR(1), Notay M(1), Trivedi M(2), Burney W(1), Vaughn AR(3), Nguyen M(4), Reiter P(5), Bosanac S(4), Yan H(1), Foolad N(4), Sivamani RK(1)(6). Author information: (1)Department of Dermatology, University of California - Davis, Sacramento, CA, U.S.A. (2)School of Medicine, University of Michigan, Ann Arbor, MI, U.S.A. (3)Drexel University College of Medicine, Philadelphia, PA, U.S.A. (4)School of Medicine, University of California - Davis, Sacramento, CA, U.S.A. (5)Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL, U.S.A. (6)Department of Biological Sciences, California State University, Sacramento, CA, U.S.A. Comment in Br J Dermatol. 2019 Feb;180(2):253-254. doi: 10.1111/bjd.17438. BACKGROUND: Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side-effects. OBJECTIVES: To compare the clinical efficacy and side-effect profiles of bakuchiol and retinol in improving common signs of cutaneous facial ageing. METHODS: This was a randomized, double-blind, 12-week study in which 44 patients were asked to apply either bakuchiol 0·5% cream twice daily or retinol 0·5% cream daily. A facial photograph and analytical system was used to obtain and analyse high-resolution photographs of patients at 0, 4, 8 and 12 weeks. Patients also completed tolerability assessment questions to review side-effects. During study visits, a board-certified dermatologist, blinded to study group assignments, graded pigmentation and redness. RESULTS: Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging. CONCLUSIONS: Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promising as a more tolerable alternative to retinol. © 2018 British Association of Dermatologists. DOI: 10.1111/bjd.16918 PMID: 29947134 [Indexed for MEDLINE]
Original source →Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early clinical studies, on cardiopulmonary fitness in individuals with Friedreich's ataxia. This 12-week, outpatient, phase 2, single-site (Children's Hospital of Philadelphia, Philadelphia, PA, USA), randomised, 2 × 2 factorial clinical trial recruited individuals aged 10-40 years with an ejection fraction of 45% or greater who were able to exercise.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →