Vitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo-sensitivity and irritation. Alternatives are emerging, but have so far been less effective. RESULTS: Levels of collagen III were significantly increased by SME, by 23% and 16% compared to bakuchiol and retinol respectively.
Relevant if you're working with retinol, hyaluronic acid, bakuchiol for aging and sensitivity.
If you're targeting aging, this research supports adding retinol to your PM routine. Effective concentration range: 0.1% based on this study.
If you're targeting aging, this research supports adding hyaluronic_acid to your AM/PM routine. Effective concentration range: 0.1% based on this study.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. J Cosmet Dermatol. 2025 Jan;24(1):e16613. doi: 10.1111/jocd.16613. Epub 2024 Dec 18. Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects.
1. J Cosmet Dermatol. 2025 Jan;24(1):e16613. doi: 10.1111/jocd.16613. Epub 2024 Dec 18. Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects. Boira C(1), Chapuis E(1), Lapierre L(1), Tiguemounine J(2), Scandolera A(1), Reynaud R(1). Author information: (1)Science and Technology, Givaudan France SAS, Pomacle, France. (2)Plastic Surgery, Polyclinic of Courlancy, Reims, France. BACKGROUND: Vitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo-sensitivity and irritation. Alternatives are emerging, but have so far been less effective. OBJECTIVE: Here, we present a Silibum marianum extract (SME) as a retinol-like ingredient providing both safety and efficacy. SME was compared to the reference compound, retinol, and to the main alternative, bakuchiol. METHODS: Skin explants from a 58-year-old donor were treated with pure retinol (0.1%), bakuchiol (0.2%), or SME (0.8%). After 5 days, collagen and hyaluronic acid levels were analyzed. A placebo-controlled study involving 57 volunteers was also conducted, with products applied twice daily for 56 days. Results were measured by AEVA-HE and VISA. RESULTS: Levels of collagen III were significantly increased by SME, by 23% and 16% compared to bakuchiol and retinol respectively. Compared to bakuchiol, SME treatment increased hyaluronic acid production by 36%. In clinical tests, SME had a significantly stronger anti-wrinkle effect than bakuchiol-reducing the number of wrinkles on the forehead by 21% and their circumference by 17%-producing effects similar to retinol, and better than bakuchiol. In the self-assessment, 43% of volunteers reported discomfort while using retinol compared to 0% for the SME formulation. By enhancing levels of collagen III-the youth collagen-and hyaluronic acid in the skin, SME paves the way for the maturation of collagen I fibrils and skin plumping. CONCLUSION: With its stronger efficacy compared to bakuchiol and enhanced safety profile compared to retinol, SME may be the next generation of natural alternatives to retinoids. © 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC. DOI: 10.1111/jocd.16613 PMCID: PMC11743331 PMID: 39692756 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
Original source →Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early clinical studies, on cardiopulmonary fitness in individuals with Friedreich's ataxia. This 12-week, outpatient, phase 2, single-site (Children's Hospital of Philadelphia, Philadelphia, PA, USA), randomised, 2 × 2 factorial clinical trial recruited individuals aged 10-40 years with an ejection fraction of 45% or greater who were able to exercise.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →