DISCUSSION: The advisory board highlighted that underdiagnosis and low awareness hinder effective management.
Relevant if you're working with niacinamide, hyaluronic acid, ceramides for sensitivity and barrier dysfunction.
If you're targeting sensitivity, this research supports adding niacinamide to your AM/PM routine.
If you're targeting sensitivity, this research supports adding hyaluronic_acid to your AM/PM routine.
Translated from this study's findings, not a personal prescription. Pair with your existing protocol and your practitioner's guidance.
1. J Drugs Dermatol. 2026 Jul 1;25(7):632-640. doi: 10.36849/JDD.9575. Decoding Sensitive Skin Syndrome: International Expert Advisory Insights on Management From India and the United States of America. Friedman A, Tiwari A, Tahiliani S, Shankar K, Inamdar A, Sachdev M, Kalra K, Shetty G, Nair R, M S, Kar D, Sen D, Choudhary S.
1. J Drugs Dermatol. 2026 Jul 1;25(7):632-640. doi: 10.36849/JDD.9575. Decoding Sensitive Skin Syndrome: International Expert Advisory Insights on Management From India and the United States of America. Friedman A, Tiwari A, Tahiliani S, Shankar K, Inamdar A, Sachdev M, Kalra K, Shetty G, Nair R, M S, Kar D, Sen D, Choudhary S. BACKGROUND: Sensitive skin syndrome (SSS) is a common self-reported condition, more prevalent in women, characterized by redness, irritation, and discomfort in response to various triggers. SSS remains a multifactorial condition with overlapping symptoms and no clear correlation between sensory complaints and observable signs, complicating both diagnosis and management. This study aimed to establish expert-driven recommendations for the diagnosis, treatment, and holistic care of SSS. METHODS: In May 2024, a panel of 11 international dermatologists reviewed literature, answered questionnaires, and convened to integrate clinical experience and emerging evidence into expert recommendations on SSS diagnosis, treatment, and holistic care. RESULTS: Experts determined that SSS is a distinct medical condition requiring systematic evaluation. Recommended diagnostic approaches included patient history, physical examination, validated self-assessment tools such as Sensitive Scale-10, dermoscopy, and sensory reactivity testing to exclude other conditions. Key findings included overlap between SSS and hyperhidrosis, supporting cross-screening, and management strategies recommending low- to medium-potency topical corticosteroids for flares and pimecrolimus as a steroid-free long-term option. Dermocosmetics with panthenol, glycerin, ceramides, hyaluronic acid, and niacinamide were recommended for barrier repair, and the Cleanse, Treat, Moisturize, Protect (CTMP®) regimen was emphasized as a cornerstone of holistic skincare. DISCUSSION: The advisory board highlighted that underdiagnosis and low awareness hinder effective management. Combining pharmacological and dermocosmetic strategies improves outcomes, but education of both clinicians and patients remains a challenge. CONCLUSIONS: SSS is a clinically relevant condition requiring structured diagnostics, recognition of comorbidities, and integrated treatment. Greater awareness and education are essential to improve care.  . DOI: 10.36849/JDD.9575 PMID: 42406360 [Indexed for MEDLINE]
Original source →Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood.
Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD+) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD+ levels are associated with axonal degeneration. Nicotinamide riboside (NR) is a safe and widely available pyridine-nucleoside form of vitamin B3 and is an NAD+ precursor. To investigate if oral supplementation of synthetic NR can act as a therapeutic agent to prevent degeneration of small somatic sensory axons innervating the skin or promote regeneration of these same fibers in humans, we utilized a validated experimental model of cutaneous nerve degeneration and regeneration and conducted a placebo-controlled, double-blinded Phase 2 study.
Nicotinamide (NAM) and Polypodium leucotomos extract (PL) have demonstrated photoprotective effects, but their role in preventing UVA-induced DNA damage in humans remains unclear. To evaluate the effects of oral NAM and PL on UVA-induced erythema and thymidine dimer (TT-dimer) formation. In this intraindividual trial, 50 healthy volunteers (phototypes I-III) were randomized (1:1) to receive either NAM (2000 mg daily) or PL (Heliocare Advanced: 480 mg daily) for 30 days.
This information is for educational purposes only and is not medical advice. Individual results vary. Consult a qualified dermatologist or healthcare professional for medical concerns. Full disclaimer →