Vitamin D3 (Cholecalciferol)

INCI: Cholecalciferol

Also known as: Vitamin D

AntioxidantsactivesyntheticEmerging evidencePregnancy safe

Skinlumis Rating

Comedogenic

0/5

Irritancy

1/5

Best applied

Both

Effective range

0.0005%–0.005%

How It Works

The 'sunshine vitamin', synthesised in skin from UVB exposure. Topical form is emerging in psoriasis and barrier-repair formulations.

Binds VDR receptors in keratinocytes, regulating differentiation and immune function.

pH Range

5.0–7.0

Benefits

Supports keratinocyte differentiation
Anti-inflammatory
Useful for psoriasis

Proven For

What the evidence supports.

PsoriasisMild barrier weakness

Best For

All skin types

Avoid If

No notable contraindications reported.

Layering Order

4/10

Mid-routine serum or treatment step.

Max Safe Concentration

0.005%

Concentration range in well-formulated products: 0.0005%–0.005%

Seasonal Use

Year-round.

Nutrition Connection

Fatty fish, fortified dairy, sun exposure.

Skin Signals When You Need It

Slow healing
Recurrent eczema flares

For Estheticians & Professionals

Oral supplementation more validated for skin than topical.

Clinical Evidence

The research behind Vitamin D3 (Cholecalciferol).

2 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review

Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.

Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014

View Study →

Randomized Controlled Trial

Ceramide-dominant emollients improved skin barrier function by 63% within 6 weeks.

Draelos ZD, Ertel K, Berge C
Cutis, 2006

View Study →

Pairs Well With

Ceramide NP

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility