Uplevity

INCI: Acetyl Tetrapeptide-2

Also known as: Acetyl Tetrapeptide-2, Uplevity

PeptidespeptidesyntheticEmerging evidencePregnancy safe

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

2%–4%

How It Works

A firming peptide marketed by Lipotec for jawline and neck tightening via thymulin pathway activation.

Reactivates the thymulin signalling pathway in skin, which declines with age. Restores keratinocyte differentiation and dermal–epidermal junction integrity.

pH Range

5.0–7.0

Benefits

Tightens jawline
Improves neck contour
Restores DEJ integrity
Pairs in lifting blends

Proven For

What the evidence supports.

Loss of firmnessJawline definition

Best For

All skin types

Avoid If

No notable contraindications reported.

Layering Order

5/10

Mid-routine serum or treatment step.

Max Safe Concentration

Concentration range in well-formulated products: 2%–4%

Seasonal Use

Year-round.

Nutrition Connection

Skin Signals When You Need It

Loss of jawline definition

For Estheticians & Professionals

Massage in along jawline and neck twice daily for documented contouring effect.

Clinical Evidence

The research behind Uplevity.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review

Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.

Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019

View Study →

Systematic Review

Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.

Wilkinson HN, Hardman MJ
Maturitas, 2017

View Study →

Systematic Review

Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.

Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014

View Study →

Randomized Controlled Trial

Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.

Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013

View Study →

Pairs Well With

Peptides (Matrixyl)Niacinamide

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility