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Resveratrol

INCI: Resveratrol
Also known as: 3,5,4'-Trihydroxystilbene
AntioxidantsantioxidantbotanicalModerate evidencePregnancy safe
80
Skinlumis Rating
Comedogenic
0/5
Irritancy
1/5
Best applied
PM
Effective range
0.1%–1%
How It Works

A polyphenol from grape skin and Japanese knotweed. Activates sirtuins (the same longevity pathway involved in caloric restriction).

Activates SIRT1 deacetylase, neutralises ROS, and inhibits tyrosinase. Synergises with Vitamin C and E to extend antioxidant network.

pH Range
5.0–7.0
Benefits
  • Anti-aging
  • Antioxidant
  • Activates longevity pathways
  • Brightens
Proven For

What the evidence supports.

PhotoagingOxidative stressDullness
Best For
  • All skin types
Avoid If

No notable contraindications reported.

Layering Order
4/10

Mid-routine serum or treatment step.

Max Safe Concentration
1%

Concentration range in well-formulated products: 0.1%–1%

Seasonal Use

Year-round.

Nutrition Connection

Red wine, grapes, blueberries, peanuts.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Photosensitive in formula, light-protective packaging mandatory.

Clinical Evidence

The research behind Resveratrol.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial
Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.
Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013
View Study →
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →
Systematic Review
Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.
Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019
View Study →
Systematic Review
Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.
Wilkinson HN, Hardman MJ
Maturitas, 2017
View Study →
Pairs Well With
Vitamin CVitamin EFerulic Acid
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

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The science behind Resveratrol

2 studies from the Intelligence Vault that discuss Resveratrol.

Browse the Vault →