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Palmitoyl Tetrapeptide-7

INCI: Palmitoyl Tetrapeptide-7
Also known as: Pal-GQPR, Rigin
PeptidespeptidesyntheticModerate evidencePregnancy safe
78
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
2%–5%
How It Works

An anti-inflammaging peptide that suppresses IL-6 and other inflammatory cytokines in glycated, aging skin.

Inhibits IL-6 release from fibroblasts; modulates AGE (advanced glycation end-product) damage in mature skin.

pH Range
5.0–7.0
Benefits
  • Targets inflammaging
  • Reduces glycation damage
  • Smooths skin
  • Pairs in dual-peptide stacks
Proven For

What the evidence supports.

InflammagingGlycation damage
Best For
  • All skin types
Avoid If

No notable contraindications reported.

Layering Order
5/10

Mid-routine serum or treatment step.

Max Safe Concentration
5%

Concentration range in well-formulated products: 2%–5%

Seasonal Use

Year-round.

Nutrition Connection

Low glycaemic diet supports anti-glycation effect.

Skin Signals When You Need It
  • Sallow, yellowed mature tone (glycation)
For Estheticians & Professionals

Pair with carnosine and lipoic acid for a full anti-glycation stack.

Clinical Evidence

The research behind Palmitoyl Tetrapeptide-7.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review
Oral collagen peptides at 2.5-10g daily significantly improved skin elasticity and reduced wrinkle depth after 8-12 weeks across 11 RCTs.
Choi FD, Sung CT, Juhasz MLW, Mesinkovska NA
Journal of Drugs in Dermatology, 2019
View Study →
Systematic Review
Estrogen deficiency following menopause causes 30% reduction in skin collagen within the first 5 years.
Wilkinson HN, Hardman MJ
Maturitas, 2017
View Study →
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →
Randomized Controlled Trial
Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.
Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013
View Study →
Pairs Well With
Palmitoyl Tripeptide-1NiacinamideCarnosine
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

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