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Grapeseed Oil

INCI: Vitis Vinifera Seed Oil
Also known as: Vitis vinifera oil
EmollientsemollientbotanicalModerate evidencePregnancy safe
72
Skinlumis Rating
Comedogenic
1/5
Irritancy
0/5
Best applied
Both
Effective range
1%–100%
How It Works

A lightweight oil rich in linoleic acid and proanthocyanidins (OPCs). Suitable for acne-prone skin and as a polyphenol-rich emollient.

Linoleic acid restores barrier and reduces comedone formation; OPCs scavenge ROS.

pH Range
5.0–7.0
Benefits
  • Restores barrier
  • Antioxidant
  • Suitable for acne-prone skin
Proven For

What the evidence supports.

AcneDryness
Best For
  • All skin types
Avoid If

No notable contraindications reported.

Layering Order
7/10

Later treatment or moisturiser step.

Max Safe Concentration
100%

Concentration range in well-formulated products: 1%–100%

Seasonal Use

Year-round.

Nutrition Connection

Grapeseed oil is dietary too, antioxidant-rich.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Excellent acne-friendly carrier oil with built-in OPC antioxidants.

Clinical Evidence

The research behind Grapeseed Oil.

4 peer-reviewed studies

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review
Gut microbiome dysbiosis is significantly associated with inflammatory skin conditions including acne and rosacea.
Dréno B, Dagnelie MA, Khammari A, Corvec S
American Journal of Clinical Dermatology, 2020
View Study →
Systematic Review
EPA supplementation at 1.8g/day reduced inflammatory acne lesions by 42% over 12 weeks.
Thomsen BJ, Chow EY, Sapijaszko MJ
Journal of Cutaneous Medicine and Surgery, 2020
View Study →
Systematic Review
Vitamin D deficiency significantly associated with acne vulgaris, atopic dermatitis and psoriasis.
Mostafa WZ, Hegazy RA
Journal of Advanced Research, 2015
View Study →
Systematic Review
Androgen receptors in sebaceous glands directly regulate sebum production, establishing the hormonal basis of acne.
Makrantonaki E, Ganceviciene R, Zouboulis C
Dermato-Endocrinology, 2011
View Study →
Pairs Well With
SqualaneResveratrol
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

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