Ceramide NS
INCI: Ceramide NS
Also known as: Ceramide 2
BarrierbarrierbiotechStrong evidencePregnancy safe
85
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.05%–1%
How It Works
A skin-identical ceramide that contributes to lipid lamellae integrity. Most common ceramide in mature stratum corneum after NP.
Forms lamellar structures with cholesterol and fatty acids; maintains skin barrier homeostasis.
pH Range
4.0–7.0
Benefits
- Strengthens barrier
- Reduces TEWL
- Soothes reactive skin
Proven For
What the evidence supports.
Barrier weaknessMature dryness
Best For
- All skin types
Avoid If
No notable contraindications reported.
Layering Order
7/10
Later treatment or moisturiser step.
Max Safe Concentration
1%
Concentration range in well-formulated products: 0.05%–1%
Seasonal Use
Year-round.
For Estheticians & Professionals
Often listed in multi-ceramide blends.
Clinical Evidence
The research behind Ceramide NS.
Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →Inflammation and Allergy Drug Targets, 2014
Randomized Controlled Trial
Ceramide-dominant emollients improved skin barrier function by 63% within 6 weeks.
Draelos ZD, Ertel K, Berge C
Cutis, 2006
View Study →Cutis, 2006
Randomized Controlled Trial
Nano-hyaluronic acid significantly improved skin hydration and elasticity after 8 weeks.
Jegasothy SM, Zabolotniaia V, Bielfeldt S
Journal of Clinical and Aesthetic Dermatology, 2014
View Study →Journal of Clinical and Aesthetic Dermatology, 2014
Pairs Well With
Conflicts With
No flagged conflicts. Still, patch-test new actives.
Your Skin Compatibility
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