Ceramide AS
INCI: Ceramide AS
Also known as: Ceramide 5
BarrierbarrierbiotechModerate evidencePregnancy safe
80
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.05%–0.5%
How It Works
An α-hydroxy ceramide that contributes hydrogen-bonded stability to the stratum corneum.
Hydroxyl group provides extra hydrogen bonding sites that stabilise lamellar lipid sheets.
pH Range
4.0–7.0
Benefits
- Strengthens barrier
- Long-acting hydration
Proven For
What the evidence supports.
Barrier weakness
Best For
- All skin types
Avoid If
No notable contraindications reported.
Layering Order
7/10
Later treatment or moisturiser step.
Max Safe Concentration
0.5%
Concentration range in well-formulated products: 0.05%–0.5%
Seasonal Use
Year-round.
For Estheticians & Professionals
Component of full-spectrum ceramide blends.
Clinical Evidence
The research behind Ceramide AS.
Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.
Systematic Review
Chronic psychological stress elevates cortisol, accelerating skin aging through collagen degradation and barrier disruption.
Chen Y, Lyga J
Inflammation and Allergy Drug Targets, 2014
View Study →Inflammation and Allergy Drug Targets, 2014
Randomized Controlled Trial
Ceramide-dominant emollients improved skin barrier function by 63% within 6 weeks.
Draelos ZD, Ertel K, Berge C
Cutis, 2006
View Study →Cutis, 2006
Pairs Well With
Conflicts With
No flagged conflicts. Still, patch-test new actives.
Your Skin Compatibility
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