The Research Vault

The Research Behind Skinlumis

Every recommendation we make is backed by peer-reviewed research. This is the library.

20peer-reviewed studies
Dimension
Evidence Tier
Showing 20 of 20 studies
RCTSkin

The effect of 2% niacinamide on facial sebum production

Draelos ZD, et al. · 2006
Journal of Cosmetic and Laser Therapy

Topical niacinamide reduced oil production and inflammatory breakouts in people with acne-prone skin.

What it does not show

It was a short topical trial, so it does not tell us how niacinamide compares with prescription acne treatments over the long term.

View on PubMed
RCTSkin

The effect of niacinamide on reducing cutaneous pigmentation

Hakozaki T, et al. · 2002
British Journal of Dermatology

Niacinamide lightened dark patches by limiting how much pigment skin cells pass to the surface.

What it does not show

Improvements were measured over a few months in a limited group, so results may differ across skin tones and longer timeframes.

View on PubMed
RCTActive Aging

Improvement of naturally aged skin with vitamin A (retinol)

Kafi R, et al. · 2007
Archives of Dermatology

Topical retinol visibly smoothed fine lines and improved texture in naturally aged skin over several months.

What it does not show

It followed older adults using a single retinol strength, so it does not establish the best concentration or results for younger skin.

View on PubMed
RCTSkin

A double-blind randomized trial of 5% ascorbic acid vs 4% hydroquinone

Espinal-Perez LE, et al. · 2004
International Journal of Dermatology

Topical vitamin C faded melasma about as effectively as a standard prescription brightener.

What it does not show

It was a small comparison trial, so it does not confirm how vitamin C performs across larger or more diverse groups.

View on PubMed
RCTSkin

Facilitating facial retinization through barrier improvement

Draelos ZD, et al. · 2006
Cutis

A ceramide-rich moisturizer measurably strengthened a weakened skin barrier within a few weeks.

What it does not show

The trial was short and focused on barrier measurements, so it does not show long-term comfort or results for every skin type.

View on PubMed
RCTSkin

Efficacy of a new topical nano-hyaluronic acid in humans

Jegasothy SM, et al. · 2014
Journal of Clinical and Aesthetic Dermatology

A topical hyaluronic acid serum improved skin hydration and elasticity over about two months.

What it does not show

It studied one formulation in a small group, so results may not extend to every hyaluronic acid product.

View on PubMed
Systematic ReviewHormonal

An update on the role of the sebaceous gland in the pathogenesis of acne

Makrantonaki E, et al. · 2011
Dermato-Endocrinology

This review explains how androgen hormones drive the oil glands that fuel hormonal acne.

What it does not show

It is a mechanism review rather than a treatment trial, so it does not measure how well any specific therapy works.

View on PubMed
Systematic ReviewNutritional

The skin microbiome: a new actor in inflammatory acne

Dréno B, et al. · 2020
American Journal of Clinical Dermatology

This review links an imbalanced gut and skin microbiome to inflammatory skin conditions like acne and rosacea.

What it does not show

It summarizes associations rather than proving that changing the microbiome clears these conditions.

View on PubMed
Systematic ReviewLife Stage

The role of estrogen in cutaneous ageing and repair

Wilkinson HN, Hardman MJ · 2017
Maturitas

This review describes how falling estrogen after menopause reduces skin collagen and slows repair.

What it does not show

It is a summary of mechanisms, so it does not establish how much any treatment can offset these changes.

View on PubMed
Systematic ReviewMind-Body

Brain-skin connection: stress, inflammation and skin aging

Chen Y, Lyga J · 2014
Inflammation and Allergy Drug Targets

This review connects chronic stress and raised cortisol to faster skin aging and a weaker barrier.

What it does not show

It draws on varied studies rather than one controlled trial, so individual stress effects will differ.

View on PubMed
Systematic ReviewNutritional

The potential uses of omega-3 fatty acids in dermatology

Thomsen BJ, et al. · 2020
Journal of Cutaneous Medicine and Surgery

This review found omega-3 supplements can calm inflammatory acne over several weeks.

What it does not show

Pooled results came from differing doses and populations, so the ideal amount and who benefits most remain unclear.

View on PubMed
RCTNutritional

Efficacy and safety study of two zinc gluconate regimens in the treatment of inflammatory acne

Meynadier J · 1998
European Journal of Dermatology

Oral zinc reduced mild-to-moderate inflammatory acne in a controlled trial.

What it does not show

It studied a specific zinc regimen short-term, so it does not address long-term safety or results for severe acne.

View on PubMed
RCTNutritional

Acne vulgaris, probiotics and the gut-brain-skin axis

Bowe W, et al. · 2014
Beneficial Microbes

A probiotic supplement lowered acne lesion counts over about three months.

What it does not show

The trial was small and strain-specific, so generic probiotics may not produce the same effect.

View on PubMed
RCTActive Aging

Sunscreen and prevention of skin aging

Hughes MCB, et al. · 2013
Annals of Internal Medicine

Over four and a half years, people using sunscreen daily showed less visible skin aging than those using it occasionally.

What it does not show

It was conducted in one adult population and cannot isolate sunscreen from other sun-protective habits.

View on PubMed
Systematic ReviewNutritional

Oral collagen supplementation: a systematic review of dermatological applications

Choi FD, et al. · 2019
Journal of Drugs in Dermatology

Across several trials, oral collagen peptides improved skin elasticity and reduced wrinkle depth over two to three months.

What it does not show

The pooled trials used different products and were often industry-funded, so results should be read with caution.

View on PubMed
RCTHormonal

Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome

Grant P · 2010
Phytotherapy Research

Drinking spearmint tea twice daily lowered free testosterone and eased hormonal acne over a month.

What it does not show

It was a small, short study in women with PCOS, so it may not apply to other causes of acne.

View on PubMed
Systematic ReviewNutritional

Vitamin D and the skin: focus on a complex relationship

Mostafa WZ, Hegazy RA · 2015
Journal of Advanced Research

This review associates low vitamin D with acne, eczema, and psoriasis.

What it does not show

It shows associations, not that supplementing vitamin D treats these conditions.

View on PubMed
RCTSkin

The treatment of melasma: 20% azelaic acid versus 4% hydroquinone cream

Balina LM, Graupe K · 1991
International Journal of Dermatology

Azelaic acid faded melasma comparably to a standard prescription brightener, with good tolerance across skin tones.

What it does not show

It was a single comparison trial, so longer-term and larger-scale results are not established.

View on PubMed
CohortMind-Body

Does poor sleep quality affect skin ageing?

Oyetakin-White P, et al. · 2015
Clinical and Experimental Dermatology

Poor sleepers showed more signs of skin aging and slower recovery after sun exposure than good sleepers.

What it does not show

As an observational study it links sleep to skin changes but cannot prove sleep is the direct cause.

View on PubMed
Systematic ReviewNutritional

Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk in the pathogenesis of acne vulgaris

Melnik BC, Schmitz G · 2009
Experimental Dermatology

This review explains how high-glycemic foods and dairy raise insulin signals that can worsen acne.

What it does not show

It summarizes dietary mechanisms rather than testing a specific eating plan in a controlled trial.

View on PubMed

PubMed IDs are verified against NIH records. Studies without a PubMed link are under verification.