RCTSkin
The effect of 2% niacinamide on facial sebum production
Draelos ZD, et al. · 2006
Journal of Cosmetic and Laser Therapy
Topical niacinamide reduced oil production and inflammatory breakouts in people with acne-prone skin.
What it does not show
It was a short topical trial, so it does not tell us how niacinamide compares with prescription acne treatments over the long term.
View on PubMed→RCTSkin
The effect of niacinamide on reducing cutaneous pigmentation
Hakozaki T, et al. · 2002
British Journal of Dermatology
Niacinamide lightened dark patches by limiting how much pigment skin cells pass to the surface.
What it does not show
Improvements were measured over a few months in a limited group, so results may differ across skin tones and longer timeframes.
View on PubMed→RCTActive Aging
Improvement of naturally aged skin with vitamin A (retinol)
Kafi R, et al. · 2007
Archives of Dermatology
Topical retinol visibly smoothed fine lines and improved texture in naturally aged skin over several months.
What it does not show
It followed older adults using a single retinol strength, so it does not establish the best concentration or results for younger skin.
View on PubMed→RCTSkin
A double-blind randomized trial of 5% ascorbic acid vs 4% hydroquinone
Espinal-Perez LE, et al. · 2004
International Journal of Dermatology
Topical vitamin C faded melasma about as effectively as a standard prescription brightener.
What it does not show
It was a small comparison trial, so it does not confirm how vitamin C performs across larger or more diverse groups.
View on PubMed→RCTSkin
Facilitating facial retinization through barrier improvement
Draelos ZD, et al. · 2006
Cutis
A ceramide-rich moisturizer measurably strengthened a weakened skin barrier within a few weeks.
What it does not show
The trial was short and focused on barrier measurements, so it does not show long-term comfort or results for every skin type.
View on PubMed→RCTSkin
Efficacy of a new topical nano-hyaluronic acid in humans
Jegasothy SM, et al. · 2014
Journal of Clinical and Aesthetic Dermatology
A topical hyaluronic acid serum improved skin hydration and elasticity over about two months.
What it does not show
It studied one formulation in a small group, so results may not extend to every hyaluronic acid product.
View on PubMed→Systematic ReviewHormonal
An update on the role of the sebaceous gland in the pathogenesis of acne
Makrantonaki E, et al. · 2011
Dermato-Endocrinology
This review explains how androgen hormones drive the oil glands that fuel hormonal acne.
What it does not show
It is a mechanism review rather than a treatment trial, so it does not measure how well any specific therapy works.
View on PubMed→Systematic ReviewNutritional
The skin microbiome: a new actor in inflammatory acne
Dréno B, et al. · 2020
American Journal of Clinical Dermatology
This review links an imbalanced gut and skin microbiome to inflammatory skin conditions like acne and rosacea.
What it does not show
It summarizes associations rather than proving that changing the microbiome clears these conditions.
View on PubMed→Systematic ReviewLife Stage
The role of estrogen in cutaneous ageing and repair
Wilkinson HN, Hardman MJ · 2017
Maturitas
This review describes how falling estrogen after menopause reduces skin collagen and slows repair.
What it does not show
It is a summary of mechanisms, so it does not establish how much any treatment can offset these changes.
View on PubMed→Systematic ReviewMind-Body
Brain-skin connection: stress, inflammation and skin aging
Chen Y, Lyga J · 2014
Inflammation and Allergy Drug Targets
This review connects chronic stress and raised cortisol to faster skin aging and a weaker barrier.
What it does not show
It draws on varied studies rather than one controlled trial, so individual stress effects will differ.
View on PubMed→Systematic ReviewNutritional
The potential uses of omega-3 fatty acids in dermatology
Thomsen BJ, et al. · 2020
Journal of Cutaneous Medicine and Surgery
This review found omega-3 supplements can calm inflammatory acne over several weeks.
What it does not show
Pooled results came from differing doses and populations, so the ideal amount and who benefits most remain unclear.
View on PubMed→RCTNutritional
Efficacy and safety study of two zinc gluconate regimens in the treatment of inflammatory acne
Meynadier J · 1998
European Journal of Dermatology
Oral zinc reduced mild-to-moderate inflammatory acne in a controlled trial.
What it does not show
It studied a specific zinc regimen short-term, so it does not address long-term safety or results for severe acne.
View on PubMed→RCTNutritional
Acne vulgaris, probiotics and the gut-brain-skin axis
Bowe W, et al. · 2014
Beneficial Microbes
A probiotic supplement lowered acne lesion counts over about three months.
What it does not show
The trial was small and strain-specific, so generic probiotics may not produce the same effect.
View on PubMed→RCTActive Aging
Sunscreen and prevention of skin aging
Hughes MCB, et al. · 2013
Annals of Internal Medicine
Over four and a half years, people using sunscreen daily showed less visible skin aging than those using it occasionally.
What it does not show
It was conducted in one adult population and cannot isolate sunscreen from other sun-protective habits.
View on PubMed→Systematic ReviewNutritional
Oral collagen supplementation: a systematic review of dermatological applications
Choi FD, et al. · 2019
Journal of Drugs in Dermatology
Across several trials, oral collagen peptides improved skin elasticity and reduced wrinkle depth over two to three months.
What it does not show
The pooled trials used different products and were often industry-funded, so results should be read with caution.
View on PubMed→RCTHormonal
Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome
Grant P · 2010
Phytotherapy Research
Drinking spearmint tea twice daily lowered free testosterone and eased hormonal acne over a month.
What it does not show
It was a small, short study in women with PCOS, so it may not apply to other causes of acne.
View on PubMed→Systematic ReviewNutritional
Vitamin D and the skin: focus on a complex relationship
Mostafa WZ, Hegazy RA · 2015
Journal of Advanced Research
This review associates low vitamin D with acne, eczema, and psoriasis.
What it does not show
It shows associations, not that supplementing vitamin D treats these conditions.
View on PubMed→RCTSkin
The treatment of melasma: 20% azelaic acid versus 4% hydroquinone cream
Balina LM, Graupe K · 1991
International Journal of Dermatology
Azelaic acid faded melasma comparably to a standard prescription brightener, with good tolerance across skin tones.
What it does not show
It was a single comparison trial, so longer-term and larger-scale results are not established.
View on PubMed→CohortMind-Body
Does poor sleep quality affect skin ageing?
Oyetakin-White P, et al. · 2015
Clinical and Experimental Dermatology
Poor sleepers showed more signs of skin aging and slower recovery after sun exposure than good sleepers.
What it does not show
As an observational study it links sleep to skin changes but cannot prove sleep is the direct cause.
View on PubMed→Systematic ReviewNutritional
Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk in the pathogenesis of acne vulgaris
Melnik BC, Schmitz G · 2009
Experimental Dermatology
This review explains how high-glycemic foods and dairy raise insulin signals that can worsen acne.
What it does not show
It summarizes dietary mechanisms rather than testing a specific eating plan in a controlled trial.
View on PubMed→