TGF-β

INCI: Transforming Growth Factor Beta

Also known as: TGF-beta

AdvancedpeptidebiotechEmerging evidenceNot for pregnancy

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

0.0001%–0.001%

How It Works

A cytokine that strongly stimulates collagen and extracellular matrix synthesis. Used in advanced anti-aging serums.

Binds TGF-β receptors on fibroblasts, activating Smad pathways to up-regulate collagen-I, collagen-III, and elastin.

pH Range

5.0–7.0

Benefits

Strong collagen stimulation
Improves elasticity
Wound healing

Proven For

What the evidence supports.

PhotoagingWound healing

Best For

All skin types

Avoid If

History of keloids

Layering Order

5/10

Mid-routine serum or treatment step.

Max Safe Concentration

0.001%

Concentration range in well-formulated products: 0.0001%–0.001%

Seasonal Use

Year-round.

For Estheticians & Professionals

Caution in keloid-prone clients, TGF-β drives scar formation.

Clinical Evidence

The research behind TGF-β.

1 peer-reviewed study

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial

Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.

Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013

View Study →

Pairs Well With

EGFPeptides (Matrixyl)

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility