IGF (Insulin-like Growth Factor)

INCI: sh-Oligopeptide-2
Also known as: IGF-1
AdvancedpeptidebiotechEmerging evidenceNot for pregnancy
70
Skinlumis Rating
Comedogenic
0/5
Irritancy
0/5
Best applied
Both
Effective range
0.0001%–0.001%
How It Works

A growth factor that promotes cell survival and protein synthesis. Less validated dermatologically than EGF or FGF.

Binds IGF-1R on keratinocytes and fibroblasts, promoting survival, proliferation, and protein synthesis.

pH Range
5.0–7.0
Benefits
  • Anti-apoptotic
  • Supports tissue regeneration
Proven For

What the evidence supports.

Mature skin
Best For
  • All skin types
Avoid If
  • Active malignancy
Layering Order
5/10

Mid-routine serum or treatment step.

Max Safe Concentration
0.001%

Concentration range in well-formulated products: 0.0001%–0.001%

Seasonal Use

Year-round.

Nutrition Connection

Dietary protein supports IGF-1 production.

Skin Signals When You Need It

No specific deficiency signals tracked for this ingredient.

For Estheticians & Professionals

Emerging cosmeceutical, manage expectations.

Clinical Evidence

The research behind IGF (Insulin-like Growth Factor).

1 peer-reviewed study

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Systematic Review
High glycemic index diet and dairy elevate IGF-1 and insulin, directly stimulating sebocyte proliferation and acne.
Melnik BC, Schmitz G
Experimental Dermatology, 2009
View Study →
Pairs Well With
EGFFGF
Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility

Sign up to see how IGF (Insulin-like Growth Factor) fits your skin archetype and personalised protocol.