FGF (Fibroblast Growth Factor)

INCI: sh-Polypeptide-1

Also known as: bFGF, FGF-2

AdvancedpeptidebiotechEmerging evidenceNot for pregnancy

Skinlumis Rating

Comedogenic

0/5

Irritancy

0/5

Best applied

Both

Effective range

0.0001%–0.001%

How It Works

A growth factor that directly stimulates fibroblast proliferation and angiogenesis. A staple in cosmeceutical 'growth factor cocktails'.

Binds FGFR on dermal fibroblasts, driving proliferation, collagen synthesis, and angiogenesis.

pH Range

5.0–7.0

Benefits

Stimulates fibroblasts
Supports collagen synthesis
Smooths skin

Proven For

What the evidence supports.

PhotoagingPost-procedure

Best For

All skin types

Avoid If

Active malignancy

Layering Order

5/10

Mid-routine serum or treatment step.

Max Safe Concentration

0.001%

Concentration range in well-formulated products: 0.0001%–0.001%

Seasonal Use

Year-round.

For Estheticians & Professionals

Pair with EGF for keratinocyte + fibroblast dual stimulation post-laser.

Clinical Evidence

The research behind FGF (Fibroblast Growth Factor).

1 peer-reviewed study

Every claim on this page traces to published research. Findings below are drawn from randomized trials and systematic reviews, each links to the study on PubMed.

Randomized Controlled Trial

Daily sunscreen use reduced photoaging markers by 24% over 4.5 years compared to discretionary use.

Hughes MCB, Williams GM, Baker P, Green AC
Annals of Internal Medicine, 2013

View Study →

Pairs Well With

EGFPeptides (Matrixyl)

Conflicts With

No flagged conflicts. Still, patch-test new actives.

Your Skin Compatibility